Validity of SOFA Score as Predictor of Mortality in Critically-ill Burn Patients
- Conditions
- Mortality Prediction
- Interventions
- Other: SOFA score
- Registration Number
- NCT03930108
- Lead Sponsor
- Indonesia University
- Brief Summary
SOFA score is valid for mortality predictor for critically-ill patient in high care and intensive care burn unit
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 169
- adult patients (age 18 and above) who admitted to burn unit during sampling period
- patients discharged or deceased less than 24 hours of admission
- patients referred to other hospital within 30 days admission
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Mortality outcome SOFA score -
- Primary Outcome Measures
Name Time Method SOFA score Discrimination 30 days from admission SOFA score ability to discriminate outcomes based on variable scores: PaO2/FiO2; MAP/vasoactive treatment; serum creatinine or 24-h diuresis; platelet count; serum bilirubin; GCS
Correlation between SOFA score variables with outcome 30 days from admission Correlation between patient outcomes with each SOFA score variable: PaO2/FiO2; MAP/vasoactive treatment; serum creatinine or 24-h diuresis; platelet count; serum bilirubin; GCS
SOFA score Calibration 30 days from admission SOFA score cutoff to predict outcome based on variable scores: PaO2/FiO2; MAP/vasoactive treatment; serum creatinine or 24-h diuresis; platelet count; serum bilirubin; GCS
- Secondary Outcome Measures
Name Time Method SOFA score: Mean Arterial Pressure (MAP) or vasoactive agent usage Day 1 The score for MAP or vasoactive agent usage variable cutoff:
0 point for MAP \>=70 mmHg;
1. point for MAP \<70 mmHg;
2. points for dopamine \<= 5 mcg/kg/min OR dobutamine any dose;
3. points for dopamine \>5 mcg/kg/min OR norepinephrine or epinephrine \<=0.1 mcg/kg/min;
4. points for dopamine \>15 mcg/kg/min OR norepinephrine or epinephrine \>0.1 mcg/kg/min.SOFA score: Serum creatinine or 24-hour diuresis Day 1 The score for serum creatinine or 24-hour diuresis variable cutoff:
0 point for creatinine \<1.2 mg/dL;
1. point for creatinine 1.2 - 1.9 mg/dL;
2. points for creatinine 2.0 - 3.4 mg/dL;
3. points for creatinine 3.5 - 4.9 mg/dL OR diuresis \<500 mL/24h;
4. points for creatinine \>5.0 mg/dL OR diuresis \<200 mL/24h.Patient outcome 30 days from admission Patient outcome within 30 days of admission to burn units: deceased or survived
SOFA score: Serum Bilirubin Day 1 The score for serum bilirubin variable cutoff:
0 point for \<1.2 mg/dL;
1. point for 1.2 - 1.9 mg/dL;
2. points for 2.0 - 5.9 mg/dL;
3. points for 6.0 - 11.9 mg/dL;
4. points for \>12.0 mg/dL.SOFA score: Partial Oxygen Pressure (PaO2)/ Fraction of Inspired Oxygen (FiO2) Day 1 The score for PaO2/FiO2 variable cutoff:
0 point for \>400 mmHg;
1. point for \<400 mmHg;
2. points for \<300 mmHg;
3. points for \<200 mmHg with respiratory support;
4. points for \<100 mmHg with respiratory support.SOFA score: Glasgow Coma Scale (GCS) Day 1 The score for GCS variable cutoff:
0 point for 15;
1. point for 13 - 14;
2. points for 10 - 12;
3. points for 6 - 9;
4. points for \<6L.SOFA score: Platelet count Day 1 The score for platelet count variable cutoff:
0 point for \>=150 x10\^3/mm\^3;
1. point for \<150 x10\^3/mm\^3;
2. points for \<100 x10\^3/mm\^3;
3. points for \<50 x10\^3/mm\^3;
4. points for \<20 x10\^3/mm\^3.
Trial Locations
- Locations (1)
Rumah Sakit Cipto Mangunkusumo
🇮🇩Jakarta Pusat, DKI Jakarta, Indonesia