Expiratory airflow limitation in subjects with obesity

Recruiting

• Conditions: obesity overweight; 10038716

• Registration Number: NL-OMON32007
• Lead Sponsor: Medisch Centrum Alkmaar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Inclusion criteria obese population:;Male/female, age 25-60
BMI (body mass index) 30-40 kg/m2
Non or ex smokers with < 10 packyears;Inclusion criteria control population:;Male/female, age 25-60
BMI (body mass index) 18.5-25 kg/m2
Non or ex smokers with <10 packyears

Exclusion Criteria

asthma
COPD (FEV1/IVC<0.70)
reversibility >9% in FEV1 (400 microgram salbutamol)
other significant neuromuscular, cardiac or lung disease;Exclusie criteria controle population:
asthma
COPD (FEV1/FVC<70)
any other significant neuromuscular, cardial of pulmonary disease
reversibility >9% in FEV1 (400 microgram salbutamol);Exclusion criteria control population:
No asthma
No COPD (FEV1/FVC<70)
No other significant neuromuscular, cardiac or lung disease
No reversibility >9% in FEV1 (400 microgram salbutamol)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>FEF25-75/FVC<br /><br>mid inspiratory Xrs minus mid expiratory Xrs at 8 Herz (cmH20.s/L)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Spirometry: FEV1(L), FVC(L), IC(L), VC max(L),<br /><br>Helium rebreathing: FRC, ERV, TLC<br /><br>Body plethysmography: Pressure-flow loop<br /><br>Forced oscillation technique: Rrs-8 (cmH20.s/L)<br /><br>Frequence dependency<br /><br>Resonance frequency<br /><br>Baseline Xrs, Rrs<br /><br>Anthropometrical data</p><br>