Effect of probiotic on management of critically ill patients

Not Applicable

• Conditions: sepsis.; Sepsis, unspecified

• Registration Number: IRCT201112143320N6
• Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1) critically ill patients admitted to the surgical ICU with positive SIRS and APACHE II score 15 to 30; 2) receiving enteral nutrition; 3) aging 18-40 years old; 4) expected to stay in ICU for at least 7 days. Exclusion criteria: 1) pregnant and lactating women; 2) patients who cannot tolerate enteral nutrition; 3) unstable hemodynamic; 4) smoking; 5) immune disorders and diabetes mellitus; 6) intestinal obstruction; 7) intestinal ischemia; 8) Patients who are expected to expire in the next 24 hours; 9) HIV-positive; 10) cancer; 11) bedsore; 12) bone marrow, liver or lung transplantation; 13) short bowel syndrome, pancreatitis and kidney or liver failure; 14) receiving Lactulose, mannitol, and glutamine during the study; 15) patients undergoing GI procedures (endoscopy, resection of the bowel and GI surgeries) during the study.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inflammation. Timepoint: days 1, 4, 7. Method of measurement: IL6, PCT.;Coagulation. Timepoint: days 1, 4, 7. Method of measurement: protein C.;Oxidative stress. Timepoint: days 1, 4, 7. Method of measurement: TAC, MDA.

Secondary Outcome Measures

Name	Time	Method
Mortality. Timepoint: days 1, 4, 7. Method of measurement: being live or dead.