Development of a Biomarker for Dietary Furanocoumarins
- Conditions
- CancerHealthy
- Registration Number
- NCT01142037
- Lead Sponsor
- University of Minnesota
- Brief Summary
Certain plant foods are high in furanocoumarins. Test tube and animal studies suggest that furanocoumarins may help prevent cancer. It is difficult to determine in humans if furanocoumarins do prevent cancer because there isn't an objective way to tell who has eaten these compounds. This study will develop a urine test to determine if an individual ate foods that contain furanocoumarins.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Must be at least 18 years of age
- Healthy
- History of gastrointestinal, hepatic or renal disorder
- Currently taking any prescription or over-the-counter medication
- Currently taking any herbal supplement
- Pregnant or lactating
- Allergies to foods that will be used (parsnips and parsley)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Urinary Biomarker Results for Dietary Furanocoumarins Week 1 determine the optimal conditions for furanocoumarin identification and quantification in human urine
- Secondary Outcome Measures
Name Time Method Mean Concentration of Dietary Furanocoumarin in Urine Week 1, 2 and 3 Determine dose response of dietary furanocoumarin in urine - Comparison of Pre-Dose, Low-Dose and High Dose diet of furanocoumarin in subjects' urine collected (ng/ml).
Trial Locations
- Locations (1)
Department of Food Science and Nutrition, University of Minnesota
🇺🇸St. Paul, Minnesota, United States
Department of Food Science and Nutrition, University of Minnesota🇺🇸St. Paul, Minnesota, United States