Development of a Biomarker for Dietary Furanocoumarins

Not Applicable

Completed

• Conditions: Cancer; Healthy
• Interventions: Dietary Supplement: Cooked parsnips with parsley

• Registration Number: NCT01142037
• Lead Sponsor: University of Minnesota

Brief Summary

Certain plant foods are high in furanocoumarins. Test tube and animal studies suggest that furanocoumarins may help prevent cancer. It is difficult to determine in humans if furanocoumarins do prevent cancer because there isn't an objective way to tell who has eaten these compounds. This study will develop a urine test to determine if an individual ate foods that contain furanocoumarins.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-06-09
• Study First Submitted QC: 2010-06-10
• Study First Posted: 2010-06-11
• Study Start: 2010-10
• Primary Completion: 2011-02
• Study Completion: 2011-02
• Status Verified: 2014-08
• Last Update Submitted: 2014-08-21
• Last Update Posted: 2014-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Must be at least 18 years of age
• Healthy

Exclusion Criteria

• History of gastrointestinal, hepatic or renal disorder
• Currently taking any prescription or over-the-counter medication
• Currently taking any herbal supplement
• Pregnant or lactating
• Allergies to foods that will be used (parsnips and parsley)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Furanocoumarin	Cooked parsnips with parsley	Includes participants first refraining from eating foods with furanocoumarins for one week, followed by 2 weeks of increasing furanocoumarin consumption. Participants will be asked to consume cooked parsnips and parsley.

Primary Outcome Measures

Name	Time	Method
Urinary Biomarker Results for Dietary Furanocoumarins	Week 1	determine the optimal conditions for furanocoumarin identification and quantification in human urine

Secondary Outcome Measures

Name	Time	Method
Mean Concentration of Dietary Furanocoumarin in Urine	Week 1, 2 and 3	Determine dose response of dietary furanocoumarin in urine - Comparison of Pre-Dose, Low-Dose and High Dose diet of furanocoumarin in subjects' urine collected (ng/ml).

Trial Locations

Locations (1)

Department of Food Science and Nutrition, University of Minnesota; 🇺🇸 St. Paul, Minnesota, United States