Comparsion of nebulised ketamine-dexmedetomidine versus intravenous ketamine-dexmedetomidine for awake fibreoptic intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Time required for intubation between group receiving dexmedetomidine+ketamine through intravenous route and group receiving dexmedetomidine+ketamine through nebulisation.
研究概览
简要总结
64 patients are divided into two groups randomally.group 1 will receive ketamine -dexmedetomidine intravenous route with normal saline nebulisation over 10mins.group2 will receive ketamin-dexmedetomidine through mobilisation and normal saline intravenous. When the sedation Score is less or equal to 3,fibreoptic incubation is attempted. If score more that 3 propofol+ketamine(ketofol) 1ml containing 10mg propofol and 10mg ketamine is given and amount of it required is noted. Both the groups will receive premedications and transtracheal and superior laryngeal block. The time taken for incubation is compared among both the groups along with the secondary goals .
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Pateints giving written informed consent will be taken.
- •Aged between 18-60years of both sex with ASA physical status I and II.
- •Patients with anticipated difficult airway undergoing elective surgical procedures.
排除标准
- •Any type of A-V block on electrocardiogram (ECG), heart failure, coronary heart disaese.
- •liver cirrhosis, thrombocytopenia and coagulopathies severe bradycardia current psychiatric disorder, history of seizures any respiratory disorders history of epistaxis, nasal pathology known drug allergy to the study drugs ASA III and ASA IV pregnant female Emergency procedures Patient refusal.
结局指标
主要结局
Time required for intubation between group receiving dexmedetomidine+ketamine through intravenous route and group receiving dexmedetomidine+ketamine through nebulisation.
时间窗: Time required for intubation is calculated when first reading obtained by capnograph after | entotracheal intubation. That is after 10mins of baseline till first capnograph reading.
次要结局
- the sedation score(at the end of trial drug administration)
- cough severity(while passing the fibreoptic bronchoscope)
- patient tolerance(whicle performing the procedure)
- ease of intubation(while passing the endotracheal tube through vocal cords)
- hemodynamic changes (HR,SBP,DBP,MAP,ECG,SPO2)(baseline,2mins,4mins,6mins,8mins,10mins,fibreoptic through nostril,ETT through nasopharynx,ETT through glottis,5mins after intubation and 10mins after intubation)
- recall of events and discomfort during procedure(postoperative period)
- adverse events(postoperative period)