Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

Not Applicable

• Conditions: Hip Arthroplasty
• Interventions: Drug: Sevoflurane; Drug: Desflurane

• Registration Number: NCT03259672
• Lead Sponsor: Keimyung University Dongsan Medical Center

Brief Summary

This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-08
• Study First Submitted: 2017-08-21
• Study First Submitted QC: 2017-08-21
• Last Update Submitted: 2017-08-21
• Study First Posted: 2017-08-24
• Last Update Posted: 2017-08-24
• Study Start: 2017-10-01
• Primary Completion: 2018-10-01
• Study Completion: 2018-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• ASA I-III
• Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria

• Difficult airway
• Friable teeth
• Rapid sequence induction
• Recent sore throat
• Recent upper respiratory infection
• Asthma
• Chronic obstructive pulmonary disease
• Chronic cough
• Arrhythmia
• Coronary disease
• Heart failure
• Pregnancy
• Allergy to sevoflurane
• Allergy to desflurane
• Fever after halogenated anesthetics
• Jaundice after halogenated anesthetics
• Malignant hyperthremia
• Allergy to remifentanil
• Friable teeth
• History of head and neck surgery
• Multiple intubation attempts
• Regional anesthetic agents
• Gastric tube
• Dexamethasone
• Severe hypovolemia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	-
Desflurane	Desflurane	-

Primary Outcome Measures

Name	Time	Method
Number of participants with postoperative sore throat	At 24 hr

Secondary Outcome Measures

Name	Time	Method
Number of participants with postoperative nausea	At 0, 2, 4 and 24 hr
Number of participants with shivering	At 0, 2, 4 and 24 hr
Number of participants with postoperative sore throat	At 0, 2, 4 and 24 hr
Number of participants with postoperative cough	At 0, 2, 4 and 24 hr
Number of participants with postoperative vomiting	At 0, 2, 4 and 24 hr
Number of participants with additional pain medication	At 0, 2, 4 and 24 hr
Number of participants with postoperative hoarseness	At 0, 2, 4 and 24 hr
Visual analogue scale of postoperative pain	At 0, 2, 4 and 24 hr
Requirements of analgesics	At 0, 2, 4 and 24 hr