NCT03259672Unknown不适用
Influence of Sevoflurane and Desflurane on Postoperative Sore Throat
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Number of participants with postoperative sore throat
研究概览
简要总结
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-III
- •Patients scheduled for general anesthesia with endotracheal intubation
排除标准
- •Difficult airway
- •Friable teeth
- •Rapid sequence induction
- •Recent sore throat
- •Recent upper respiratory infection
- •Chronic obstructive pulmonary disease
- •Chronic cough
- •Arrhythmia
- •Coronary disease
- •Heart failure
- •Pregnancy
- •Allergy to sevoflurane
- •Allergy to desflurane
- •Fever after halogenated anesthetics
- •Jaundice after halogenated anesthetics
- •Malignant hyperthremia
- •Allergy to remifentanil
- •Friable teeth
- •History of head and neck surgery
- •Multiple intubation attempts
- •Regional anesthetic agents
- •Gastric tube
- •Dexamethasone
- •Severe hypovolemia
研究组 & 干预措施
Sevoflurane
Active Comparator
干预措施: Sevoflurane (Drug)
Desflurane
Experimental
干预措施: Desflurane (Drug)
结局指标
主要结局
Number of participants with postoperative sore throat
时间窗: At 24 hr
次要结局
- Number of participants with postoperative nausea(At 0, 2, 4 and 24 hr)
- Number of participants with shivering(At 0, 2, 4 and 24 hr)
- Number of participants with postoperative sore throat(At 0, 2, 4 and 24 hr)
- Number of participants with postoperative cough(At 0, 2, 4 and 24 hr)
- Number of participants with postoperative vomiting(At 0, 2, 4 and 24 hr)
- Number of participants with additional pain medication(At 0, 2, 4 and 24 hr)
- Number of participants with postoperative hoarseness(At 0, 2, 4 and 24 hr)
- Visual analogue scale of postoperative pain(At 0, 2, 4 and 24 hr)
- Requirements of analgesics(At 0, 2, 4 and 24 hr)
研究者
Hyun-Chang Kim
Assistant professor
Keimyung University Dongsan Medical Center
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