NCT02376309已完成不适用
The Effect of Nandrolone Decanoate Injection and Leucine Supplementation on Muscle Loss
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- CSA Quadriceps (CT scan)
研究概览
简要总结
A decrease in muscle mass can have a profound impact on quality of life, as it can lead to decreased strength, insulin resistance, lower basal metabolic rate and obesity. With this study we investigate whether ingesting leucine or getting a ND injection will reduce the loss of muscle mass and strength.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy men 18-35 years
- •BMI between 18.5 and 30 kg/m2
排除标准
- •(Family) history of thromboembolic events
- •Recent surgery (within 6 months prior to the study)
- •Performing progressive resistance training more than three times per week in the past year
- •Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
- •Current systemic use of corticosteroids, anabolic steroids, growth hormone, testosterone, nandrolone, protein supplements, immunosuppressants or insulin, blood sugar decreasing medication or EPO
- •All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
- •Use of anti-coagulants
- •Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)
- •Liver disease
- •Heart failure
- •Allergy to nuts or soy
- •High blood pressure (>140 mmHg systolic and >90 mmHg diastolic) In case of doubt, in- or exclusion of subject will be discussed with responsible physician or principal investigator.
研究组 & 干预措施
Leu during inactivity
Experimental
Leucine supplements
干预措施: Inactivity (Behavioral)
Leu during inactivity
Experimental
Leucine supplements
干预措施: Leu (Dietary Supplement)
ND during inactivity
Experimental
Nandrolone injection
干预措施: Inactivity (Behavioral)
ND during inactivity
Experimental
Nandrolone injection
干预措施: ND (Drug)
结局指标
主要结局
CSA Quadriceps (CT scan)
时间窗: 7 days
CT scan
次要结局
- Muscle strength as measured by 1RM test(7 days)
- Muscle fiber type and CSA as measured by histochemistry from the muscle biopsy(7 days)
研究者
研究点 (1)
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