A study comparing carriage rate difference of collagen binding protein (Cnm) positive S. mutans in saliva between patients with ruptured intracranial aneurysms and those with unruptured, to confirm whether it is a risk factor of intracranial aneurysmal rupture. Multi-center retrospective observation study.
Not Applicable
- Conditions
- intracranial aneurysm
- Registration Number
- JPRN-UMIN000010404
- Lead Sponsor
- Department of Neurosurgery, Seirei Hamamatsu General Hospital
- Brief Summary
From May, 2013 to June, 2018, we had 258 cases of acute ruptured intracranial aneurysms, 238 cases of chronic postoperative ruptured intracranial aneurysms, 420 cases of preoperative unruptured intracranial aneurysms, and 105 cases of postoperative unruptured aneurysms. We compared these ruptured cases with unruptured cases. We found no statistically significant difference with p=0.810.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 1021
Inclusion Criteria
Not provided
Exclusion Criteria
Within two months after antibiotics usage. Aneurysms associated with bacterial endocarditis. Dissecting cerebral aneurysms.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To confirm carriage rate of these bacteria in ruptured intracranial aneurysmal patients is statistically higher than that of unruptured intracranial aneurysmal patients.
- Secondary Outcome Measures
Name Time Method Relationship to the follwing items with Cnm positive S. mutans; 1. past history, complication, and known risk factors. 2. aneurysmal site, shape, and size. 3. other items in the survey sheets.