Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 6
- 主要终点
- Percent correct intelligible words from trained/untrained scripts
研究概览
简要总结
Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA.
The overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how "strong" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
- •Bilingual in Spanish and Catalan or bilingual in Spanish and English
- •Different proficiency levels across languages are expected, any prior experience in both languages is acceptable
- •Intervention study: Score of 15 or higher on the Mini-Mental State Examination
- •Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination
排除标准
- •Other central nervous system or medical diagnosis that can cause symptoms
- •Other psychiatric diagnosis that can cause symptoms
- •Significant, uncorrected visual or hearing impairment that would interfere with participation
- •Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)
- •Intervention Study: Score of less than 15 on the Mini-Mental State Examination
- •Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination
研究组 & 干预措施
Lexical Retrieval Training
Naming intervention for individuals with logopenic or semantic variant PPA.
干预措施: Video-Implemented Script Training for Aphasia (VISTA) (Behavioral)
Lexical Retrieval Training
Naming intervention for individuals with logopenic or semantic variant PPA.
干预措施: Lexical Retrieval Training (LRT) (Behavioral)
Video Implemented Script Training for Aphasia
Script training intervention for individuals with nonfluent/agrammatic PPA.
干预措施: Video-Implemented Script Training for Aphasia (VISTA) (Behavioral)
Video Implemented Script Training for Aphasia
Script training intervention for individuals with nonfluent/agrammatic PPA.
干预措施: Lexical Retrieval Training (LRT) (Behavioral)
结局指标
主要结局
Percent correct intelligible words from trained/untrained scripts
时间窗: Pre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment
Percent of intelligible, scripted words for trained scripts and untrained scripts
Percent correct spoken naming of trained/untrained nouns
时间窗: Pre-phase 1, post-phase1/pre-phase 2 (4.5 weeks from treatment onset), post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment
Percent of correctly named trained pictured items and untrained pictured items
次要结局
- Connected Speech Features: Type-token ratio(Pre-phase 1, Post-phase1/pre-phase 2 (4.5 weeks from treatment onset), Post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment)
- Connected Speech Features: Mean length of utterance(Pre-phase 1, Post-phase1/pre-phase 2 (4.5 weeks from treatment onset), Post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment)
- Acoustic Features: Articulation Rate(Pre-phase 1, Post-phase1/pre-phase 2 (4.5 weeks from treatment onset), Post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment)
- Aphasia Impact Questionnaire (AIQ)(Pre-phase 1, Post-phase 2 (9 weeks from treatment onset))
- Acoustic Features: Speech-to-pause time(Pre-phase 1, Post-phase1/pre-phase 2 (4.5 weeks from treatment onset), Post-phase 2 (9 weeks from treatment onset), 6 months and 1 year post-treatment)
研究者
Stephanie Grasso
Associate Professor
University of Texas at Austin