Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Neuropsychological variables
研究概览
简要总结
The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.
详细描述
The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.
During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), cognitive experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.
For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of primary progressive aphasia
- •Right-handed
- •Native English speaker
- •Visual acuity of 20/30 corrected
- •Adequate hearing to follow conversation
- •Safe for an MRI scan
排除标准
- •Left-handedness
- •Claustrophobia
- •Presence of significant medical illness that initially or in the future could interfere with continued participation in the study
结局指标
主要结局
Neuropsychological variables
时间窗: Immediately after testing and at two years post-testing
次要结局
未报告次要终点
研究者
Marsel Mesulam
Director, Mesulam Center for Cognitive Neurology and Alzheimer's Disease
Northwestern University