The Center for the Neurobiology of Language Recovery (CNLR)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 8
- 主要终点
- Change in language and cognitive abilities as a result of treatment
研究概览
简要总结
The purpose of this study is to investigate the effects of treatment for specific language deficits in people with aphasia. In addition to language and cognitive measures, changes in brain function will also be gathered before and after the treatment is administered in order to track any changes resulting from receiving treatment.
详细描述
Naming Impairments (Anomia):
The labs of Dr. Swathi Kiran (Boston University) and Dr. David Caplan (Harvard University, Massachusetts General Hospital) will be studying language recovery in adults with anomia (naming impairments) following a stroke. Participants will receive treatment focusing on the semantic features of common objects (e.g., that birds can fly). The study will examine how naming and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Spelling/Writing Impairments (Dysgraphia):
At Johns Hopkins University, the lab of Dr. Brenda Rapp will investigate the neurobiology of language recovery in individuals with dysgraphia (spelling/writing impairments) resulting from a stroke. In this study, treatment will focus on improving spelling ability. The study will examine how spelling and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Deficits in Sentence Comprehension & Production:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aphasia following a stroke
- •Stoke was at least 1 year ago
- •Medically stable
- •Right-handed
- •Normal or 'corrected to normal' vision and hearing
- •English as primary language
- •At least a high school education
排除标准
- •History of neurological disease, head trauma, psychiatric disorders, alcoholism, or developmental speech, language, or learning disabilities
研究组 & 干预措施
Spelling and/or Writing Deficits
Language treatment will focus on improving writing and/or spelling deficits in people who have aphasia. An experimental group will receive treatment focusing on improving spelling abilities and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
干预措施: Treatment Focusing on Improving Spelling Abilities (Behavioral)
Naming Deficits
Language treatment will focus on improving naming deficits in people who have aphasia. An experimental group will receive treatment focusing on naming objects and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
干预措施: No Treatment (Behavioral)
Spelling and/or Writing Deficits
Language treatment will focus on improving writing and/or spelling deficits in people who have aphasia. An experimental group will receive treatment focusing on improving spelling abilities and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
干预措施: No Treatment (Behavioral)
Sentence Processing
Language treatment will focus on improving sentence comprehension and production deficits in people who have aphasia. An experimental group will receive treatment focusing on improving sentence processing and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
干预措施: No Treatment (Behavioral)
Naming Deficits
Language treatment will focus on improving naming deficits in people who have aphasia. An experimental group will receive treatment focusing on naming objects and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
干预措施: Treatment Focusing on Naming Objects (Behavioral)
Sentence Processing
Language treatment will focus on improving sentence comprehension and production deficits in people who have aphasia. An experimental group will receive treatment focusing on improving sentence processing and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
干预措施: Treatment Focusing on Improving Sentence Processing (Behavioral)
结局指标
主要结局
Change in language and cognitive abilities as a result of treatment
时间窗: week 0 to week 12
Standard and non-standard measures of language and cognitive abilities will be gathered at baseline (week 0) to see if language deficits improve after treatment is administered (week 12).
次要结局
- Composite change in brain function as a result of treatment(week 0 to week 12)
- Maintenance of composite changes in brain function as a result of treatment(week 12 to week 24)
- Maintenance of language and cognitive abilities as a result of treatment(week 12 to week 24)
研究者
Cynthia K Thompson
Ralph and Jean Sundin Professor of Communication Sciences
Northwestern University