Association of Periostin Levels and Chronic Sinusitis
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Difference in circulating serum periostin levels pre and post sinus surgery
研究概览
简要总结
The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such as chronic sinusitis. The investigators are interested in testing levels of periostin to see if they are higher or lower than patients without chronic sinusitis, just as periostin is higher in patients with asthma. All patients enrolled in this study will have chronic sinusitis without asthma.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with sinus disease which requires surgical intervention
- •Ability to understand and give informed consent
排除标准
- •Previous diagnosis of asthma
- •Positive methacholine challenge at screening
- •Diagnosis of cystic fibrosis
- •Concomitant use of systemic corticosteroids (except for those prescribed as part of standard pre-surgical treatment)
结局指标
主要结局
Difference in circulating serum periostin levels pre and post sinus surgery
时间窗: 10-15 weeks
Serum collected prior to and following sinus surgery will be analyzed for concentrations of the protein periostin.
次要结局
未报告次要终点
研究者
John Steinke
Associate Professor
University of Virginia