Association of Periostin Levels and Chronic Sinusitis
Withdrawn
- Conditions
- Nasal PolypsSinusitis
- Interventions
- Other: Blood draw
- Registration Number
- NCT02071667
- Lead Sponsor
- University of Virginia
- Brief Summary
The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such as chronic sinusitis. The investigators are interested in testing levels of periostin to see if they are higher or lower than patients without chronic sinusitis, just as periostin is higher in patients with asthma. All patients enrolled in this study will have chronic sinusitis without asthma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Patients with sinus disease which requires surgical intervention
- Ability to understand and give informed consent
Exclusion Criteria
- Previous diagnosis of asthma
- Positive methacholine challenge at screening
- Diagnosis of cystic fibrosis
- Concomitant use of systemic corticosteroids (except for those prescribed as part of standard pre-surgical treatment)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Subjects who require sinus surgery Blood draw -
- Primary Outcome Measures
Name Time Method Difference in circulating serum periostin levels pre and post sinus surgery 10-15 weeks Serum collected prior to and following sinus surgery will be analyzed for concentrations of the protein periostin.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Virginia
🇺🇸Charlottesville, Virginia, United States