Association of Periostin Levels and Chronic Sinusitis

Withdrawn

• Conditions: Nasal Polyps; Sinusitis

• Registration Number: NCT02071667
• Lead Sponsor: University of Virginia

Brief Summary

The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such as chronic sinusitis. The investigators are interested in testing levels of periostin to see if they are higher or lower than patients without chronic sinusitis, just as periostin is higher in patients with asthma. All patients enrolled in this study will have chronic sinusitis without asthma.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-02-20
• Study First Submitted QC: 2014-02-21
• Study First Posted: 2014-02-26
• Study Start: 2014-09
• Primary Completion: 2016-09
• Study Completion: 2016-10
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-01
• Last Update Posted: 2017-05-04

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients with sinus disease which requires surgical intervention
• Ability to understand and give informed consent

Exclusion Criteria

• Previous diagnosis of asthma
• Positive methacholine challenge at screening
• Diagnosis of cystic fibrosis
• Concomitant use of systemic corticosteroids (except for those prescribed as part of standard pre-surgical treatment)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in circulating serum periostin levels pre and post sinus surgery	10-15 weeks	Serum collected prior to and following sinus surgery will be analyzed for concentrations of the protein periostin.

Trial Locations

Locations (1)

University of Virginia; 🇺🇸 Charlottesville, Virginia, United States