The effect of periarticular dextrose prolotherapy and ozone on knee osteoarthritis
Phase 3
Completed
- Conditions
- knee arthritis.Bilateral primary osteoarthritis of kneeM17.0
- Registration Number
- IRCT20190415043279N8
- Lead Sponsor
- Sanandaj University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
Patients with grade 2 and 3 osteoarthritis of both knees
Age over 50 years
Morning stiffness less than 30 minutes
Crepitus in active knee movements
Bone sensitivity
Bone enlargement
Lack of heat in the joint touch
Exclusion Criteria
Injection of steroid drugs in the last 2 months
Diabetes
Indication for surgical arthroplasty
Previous injection treatment with dextrose
Knee infection in the last three months
Knee inflammation
Daily use of drugs
History of inflammatory joint disease
Arthritis after infection
Joint dysplasia
Congenital anomalies
Crystalopathy
Arthritis after injury
Malignancy
Vascular necrosis
Obesity
Grade 4 osteoarthritis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intensity of pain. Timepoint: Before intervention, one month after intervention, two months after intervention. Method of measurement: Visual Analogue Scale (VAS).;Physical function. Timepoint: Before intervention, one month after intervention, two months after intervention. Method of measurement: WOMAC Index.;Kellgrn lawrence index. Timepoint: Before intervention, one month after intervention, two months after intervention. Method of measurement: Radiological imaging.
- Secondary Outcome Measures
Name Time Method Possible side effects. Timepoint: During the treatment period until the end of the intervention. Method of measurement: Any possible side effects such as pain, swelling, itching, redness and warmth at the injection site are measured and recorded.