microRNA and Delirium After Hip and Knee Fracture
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 52
- 主要终点
- The level of microRNA in cerebrospinal fluid and serum
研究概览
简要总结
The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.
详细描述
Postoperative delirium is one of the most common postoperative complications in elderly patients.It has been shown that postoperative delirium has independent adverse effects on short and long-term mortality and morbidity, including poor functional recovery, postoperative cognitive dysfunction, deterioration in quality of life, and increased costs. However, at the present time, postoperative delirium is a clinical phenomenon, and its neuropathogenesis remains unknown. This gap in knowledge has become a barrier that limits further studies, including the development of potential interventions for postoperative delirium.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •65 years old or older
- •candidates for spinal anesthesia
- •Non language communication barriers
排除标准
- •past medical history of neurological and psychiatric diseases including AD, other forms of dementia, stroke, or psychosis;
- •severe visual or hearing impairment;
- •unwillingness to comply with the protocol or procedures.
结局指标
主要结局
The level of microRNA in cerebrospinal fluid and serum
时间窗: through study completion, an average of 1 year
All of the participants had spinal anesthesia for the scheduled surgery. Two milliliter of CSF was collected from a spinal needle by anesthesiologists during the spinal anesthesia before the administration of the local anesthetic. Blood samples were collected from patients prior to spinal anesthesia.
次要结局
未报告次要终点
研究者
Mian Peng,MD
vice professor
Zhongnan Hospital