Study of Postoperative Delirium in Elderly People After Orthopedic Surgery

Completed

• Conditions: Postoperative Delirium
• Interventions: Other: interview

• Registration Number: NCT02817386
• Lead Sponsor: Zhongnan Hospital

Brief Summary

The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.

Detailed Description

Postoperative delirium is one of the most common postoperative complications in elderly patients.It has been shown that postoperative delirium has independent adverse effects on short and long-term mortality and morbidity, including poor functional recovery, postoperative cognitive dysfunction, deterioration in quality of life, and increased costs. However, at the present time, postoperative delirium is a clinical phenomenon, and its neuropathogenesis remains unknown. This gap in knowledge has become a barrier that limits further studies, including the development of potential interventions for postoperative delirium.

Study Timeline

• Study Start: 2015-03
• Primary Completion: 2016-01
• Study Completion: 2016-02
• Study First Submitted: 2016-06-22
• Study First Submitted QC: 2016-06-26
• Study First Posted: 2016-06-29
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-22
• Last Update Posted: 2017-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

1. 65 years old or older
2. candidates for spinal anesthesia
3. Non language communication barriers

Exclusion Criteria

1. past medical history of neurological and psychiatric diseases including AD, other forms of dementia, stroke, or psychosis;
2. severe visual or hearing impairment;
3. unwillingness to comply with the protocol or procedures.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
POD and Non-POD;	interview	Trained clinical research assistants interviewed the patients on the first and second day post surgery. The assessment of post deliriu (POD) was performed once per day between 8:00 AM to 10:00 AM. Patient notes were not reviewed for episodes of delirium which could occur outside the time of assessment. The clinical research assistants who performed the delirium assessments in this study had good training and went through quality control procedures. We used state-of-the-art delirium detection methods, which tend to report a higher incidence of delirium. The interview included the Confusion Assessment Method (CAM) and Memorial Delirium Assessment Scale (MDAS).

Primary Outcome Measures

Name	Time	Method
The level of microRNA in cerebrospinal fluid and serum	through study completion, an average of 1 year	All of the participants had spinal anesthesia for the scheduled surgery. Two milliliter of CSF was collected from a spinal needle by anesthesiologists during the spinal anesthesia before the administration of the local anesthetic. Blood samples were collected from patients prior to spinal anesthesia.