Effects of Electrolyzed-Reduced Water(ERW) on the Activities of Antioxidant Enzymes in Healthy Adults: Randomized double-blind placebo-controlled trial

Not Applicable

Active, not recruiting

Conditions: Not Applicable

Registration Number: KCT0003808

Lead Sponsor: Bundang Jesaeng Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Active, not recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

(1) Subjects who voluntarily agreed to participate and signed in informed consent
(2) Healthy Volunteers 18-65 years old (include patients with controlled hypertension or diabetes mellitus)

Exclusion Criteria

(1) Smokers
(2) Subjects who consume Alcohol more than 4 regular(250cc) cups of beers or 5 small (50cc) glasses of Korean distlled spirit(men) and more than 2 regular(250cc) cups of beers or 2.5 small (50cc) glasses of Korean distlled spirit for (women) and/or of drinking for more than 2 weeks
(3) Pregnant Women
(4) Uncontrolled diabetes mellitus
(5) Uncontrolled High blood pessure
(6) Subjects who implented Cardiac pacemaker
(7) Subjects who taking Antioxidant supplements; vit C, vit E, flavonoids, bilberry, CoQ19, glutathione, omega-3, Mg, Mn, Zn ( 2 weeks of Wash-out period is needed before enrollement)

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biomarkers of Oxidative Stress: Antioxidant Enzymes (SOD(Superoxide Dismutase), GPX(Glutathione Peroxidase), CAT(Catalase)), MDA(Malondialdehyde), 8-OHdG(8-hydroxy deoxyguanosine), oxidized LDL, d-ROMs (Reactive Oxygen Metabolites- derived compounds), BAP (Biological Antioxidant Potential)

Secondary Outcome Measures

Name	Time	Method
K cell activity, A.G.E.(Advanced glycation end-product), Complete blood count and Biochemistry Profile;Bio-Impedance Analysis (Phase angle, body composition);heart rate variability (SDNN, RMSSD, PSI, TP, LF, HF, LF/HF);Cardio-ankle vascular index (CAVI);Short Form-36 Health Survey,Brief Encounter Psychosocial Instrument-Korean version,Brief fatigue inventory,Fatigue Severity Scale;Adverse events