Safety of Hormonal Contraceptives Therapies in Polycystic Ovary Syndrome (PCOS) Women
- Conditions
- Polycystic Ovary Syndrome
- Interventions
- Drug: Oral contraceptive plus metforminDrug: oral contraceptive
- Registration Number
- NCT00842140
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
The purpose of this study to assess early markers of cardiovascular disease in women with polycystic ovary syndrome in use of oral contraceptive containing ethynilestradiol and chlormadinone acetate alone or associated with Spironolactone.
- Detailed Description
Polycystic ovary syndrome (PCOS) is associated with comorbidities that may contribute to increased risk of cardiovascular disease (CVD). Oral contraceptives (OC) have been the mainstay of PCOS pharmacological therapy for decades. However, in non-hyperandrogenic women, OC use is associated with higher risk of cardiovascular disease, raising concern about a possible worsening of the unfavorable metabolic and cardiovascular profile of PCOS patients. There is lack of evidence about the impact of PCOS pharmacological therapies on cardiovascular risk markers and the long-term safety of these drugs in PCOS has not been established. The aim of this study is to compare the effect of an OC alone or associated with an anti-androgenic drug (spironolactone) on echografic cardiovascular risk markers, metabolic and hemostatic variables.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 75
- age between 18 and 35 years
- diagnosis of PCOS by Rotterdam Consensus
- smoking, alcoholism, drug addiction;
- current pregnancy;
- current or previous use (up to two months before the study) of oral, vaginal, monthly injectable, or transdermal combined hormonal contraceptives;
- current or previous use (up to six months before the study) of a long-lasting hormonal contraceptive method (injectable, implant, or intrauterine device);
- antiandrogenic or hypoglycemic drugs, anti-inflammatory drugs, or statins;
- presence of systemic diseases (DM2, cardiovascular disease, autoimmune diseases, liver disease, thyroid disease, or congenital renal hyperplasia);
- personal history of arterial or venous thrombosis; chronic or acute inflammatory processes;
- puerperium of 12 weeks or less
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 3 Oral contraceptive plus metformin The patient will receive an oral contraceptive (0,03mg ethynylestradiol and 2mg chlormadinone acetate) plus 850 mg metformin. 1 oral contraceptive This group will receive an oral contraceptive containing 0,03mg ethynylestradiol and 2mg chlormadinone acetate 2 Oral contraceptive plus spironolactone The patient will receive an oral contraceptive (0,03mg ethynylestradiol and 2mg chlormadinone acetate) plus 100 mg spironolactone. One pill each once a day for twelve months.
- Primary Outcome Measures
Name Time Method To compare the effect of an oral contraceptive alone or associated with an anti-androgenic drug (spironolactone) or associated with metformin on echografic cardiovascular risk markers. 12 months
- Secondary Outcome Measures
Name Time Method to compare the effect of an oral contraceptive alone or associated with an anti-androgenic drug (spironolactone) or associated with metformin on hemostatic variables. 12 months to compare the effect of an oral contraceptive alone or associated with an anti-androgenic drug (spironolactone) or associated with metformin on metabolic variables. 12 months to compare the effect of an oral contraceptive alone or associated with an anti-androgenic drug (spironolactone) or associated with metformin on seric cardiovascular risk markers. 12 months
Trial Locations
- Locations (1)
University of Sao Paulo
🇧🇷Ribeirao Preto, Sao Paulo, Brazil