Do resident microorganisms on human skin affect the sunburn response?

Not Applicable

• Conditions: Dermatology; Skin and Connective Tissue Diseases

• Registration Number: ISRCTN16557401
• Lead Sponsor: niversity of Manchester

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-10-19
• Last Update Posted: 19 December 2023
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

1. Healthy adults of any gender aged 18-40 years
2. White Caucasian (Fitzpatrick skin type I-III)
3. Able to understand and meet study requirements, and provide written informed consent

Exclusion Criteria

1. Skin sensitivity/allergy to alcohol-based skin preparations
2. Existing significant (moderate-severe) skin disease such as eczema, xerosis (dry skin), psoriasis
3. Use of antimicrobial medications in the last 3 months
4. Sunbathing/sunbed use/phototherapy in the last 3 months
5. Currently participating, or have recently participated (within the last month) in other research
6. Unable to meet the requirements for participating in the study

Additional exclusions for the main study:
1. History of photosensitivity disorder or skin cancer
2. History of bleeding disorders
3. Taking photoactive, anti-inflammatory or anti-coagulant medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
VR-induced erythema assessed visually (minimal erythema dose) and objectively by spectrophotometry at 24 hours

Secondary Outcome Measures

Name	Time	Method
1. Markers of inflammation, DNA damage, apoptosis, and cell proliferation measured by immunofluorescent staining at baseline and 24 hours<br>2. Density and diversity of skin microbiota measured by 16S rRNA sequencing at baseline and 24 hours