a New and Non Invasive Method to Calculate STI ( Systolic Time Intervals) Combined to Valsalva Maneuver in Patient With Acute Exacerbation of COPD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 189
- 试验地点
- 1
- 主要终点
- diagnosis of left ventricular dysfunction
研究概览
简要总结
The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of chronic obstructive pulmonary disease (AECOPD) and whether STIs measured under Valsalva manoeuver (VM) could improve the distinction between patients with LVD and those without LVD.
详细描述
We included patients admitted to the ED for AECOPD. Measurement of STIs included electromechanical activation time (EMAT), left ventricular ejection time and EMAT/LVET ratio. These were performed at baseline and during the first strain phase of the VM using a computerized phono and electrocardiographic method. The diagnosis of LVD was determined on the basis of clinical examination, echocardiography and brain natriuretic peptide. The values of STIs were compared between patients with and without LVD ; their diagnostic performance was assessed using the area under receiver operating characteristic curve (AUC of ROC).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Oxygen Saturation (SPO2) <90%,
- •Respiratory Rate >25c/min,
- •PaCO2 > 6 kPa et pH< 7.35.
排除标准
- •Neurological distress and hemodynamic instability
- •Confusion, agitation
- •pneumothorax
- •Non cooperative patients
- •Refusal of consent
结局指标
主要结局
diagnosis of left ventricular dysfunction
时间窗: during the first day admission in emergency department
Systolic time intervals measured at baseline and under Valsalva maneuver
次要结局
未报告次要终点
研究者
Pr. Semir Nouira
Professor
University of Monastir