STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations

Completed

• Conditions: Obstructive Chronic Bronchitis With Acute Exacerbation

• Registration Number: NCT02481908
• Lead Sponsor: University of Monastir

Brief Summary

The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of chronic obstructive pulmonary disease (AECOPD) and whether STIs measured under Valsalva manoeuver (VM) could improve the distinction between patients with LVD and those without LVD.

Detailed Description

We included patients admitted to the ED for AECOPD. Measurement of STIs included electromechanical activation time (EMAT), left ventricular ejection time and EMAT/LVET ratio. These were performed at baseline and during the first strain phase of the VM using a computerized phono and electrocardiographic method. The diagnosis of LVD was determined on the basis of clinical examination, echocardiography and brain natriuretic peptide. The values of STIs were compared between patients with and without LVD ; their diagnostic performance was assessed using the area under receiver operating characteristic curve (AUC of ROC).

Study Timeline

• Study Start: 2012-04
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Study First Submitted: 2015-05-07
• Study First Submitted QC: 2015-06-22
• Study First Posted: 2015-06-25
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-10
• Last Update Posted: 2020-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 189

Inclusion Criteria

• Oxygen Saturation (SPO2) <90%,
• Respiratory Rate >25c/min,
• PaCO2 > 6 kPa et pH< 7.35.

Exclusion Criteria

• Neurological distress and hemodynamic instability
• Confusion, agitation
• pneumothorax
• Non cooperative patients
• Refusal of consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
diagnosis of left ventricular dysfunction	during the first day admission in emergency department	Systolic time intervals measured at baseline and under Valsalva maneuver

Trial Locations

Locations (1)

CHU Fattouma Bourguiba; 🇹🇳 Monastir, Tunisia