ISRCTN54581790已完成4 期
Efficacy and safety of Cerebrolysin in the treatment of aphasia after acute ischemic stroke
The foundation for the study of neuroscience and neuroregeneration (SSNN)0 个研究点目标入组 132 人开始时间: 2020年4月29日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 132
研究概览
简要总结
2024 Preprint results in https://doi.org/10.1101/2024.02.23.24303302 (added 19/08/2024)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Current inclusion criteria as of 04/06/2020:
- •1. Radiologically (CT or MRI) and clinically confirmed diagnosis of acute ischemic stroke in the left MCA territory
- •2. Broca or mixed non-fluent aphasia
- •3. Inclusion in the study between 3 and 5 days post-stroke
- •4. Right-handedness
- •5. Romanian as language of daily use
- •6. Signed informed consent
- •Previous inclusion criteria:
- •1. Radiologically (CT or MRI) and clinically confirmed diagnosis of acute ischemic stroke in the left MCA territory
- •2. Broca or mixed non-fluent aphasia
- •3. Inclusion in the study between 5 and 30 days post-stroke
- •4. Right-handedness
- •5. Romanian as language of daily use
- •6. Signed informed consent
排除标准
- •1. Prior symptomatic ischemic or hemorrhagic stroke
- •2. Severe comprehension deficit that may compromise informed consent or understanding of instructions such as fluent aphasias (ex. Wernicke aphasia), or global aphasias
- •3. Contraindications to MRI
- •4. Preexisting neurodegenerative or psychiatric disease
- •5. Epilepsy or EEG-documented epileptic discharges
- •6. Severe chronic renal or liver failure; (AST, ALT > 4 times normal values, creatinine > 4)
- •7. Life-threatening diseases
- •8. Auditory or visual deficits that cannot be corrected and might impair testing
研究者
相似试验
已完成
不适用
Evaluation of efficacy and safety of Cerebrolysin as add-on therapy in patients with acute stroke after failed recanalisation therapyAcute ischemic strokeCirculatory SystemStroke, not specified as haemorrhage or infarctionISRCTN15233803niversity Hospital Centre Zagreb46
已完成
3 期
Can Cerebrolysin improve recovery after traumatic brain injury?Traumatic brain injury (TBI) with Glasgow Coma Scale (GCS) scores between 7 and 12.Nervous System DiseasesISRCTN17097163EN: The foundation for the study of neuroscience and reuroregeneration (RO: Fundatia pentru Studiul Nanoneurostiintelor si Neuroregenerarii)142
已完成
3 期
Cerebrolysin to prevent intracranial bleeding after intravenous thrombolysis (blood clot) in patients with ischemic strokeIschemic strokeCirculatory SystemISRCTN87656744State Autonomous Institution of Health Interregional Clinical Diagnostic Center341
招募中
1 期
Is Cerebrolysin efficient in neurorecovery after moderate-severe traumatic brain injury?Moderate-severe traumatic brain injuryMedDRA version: 26.1Level: LLTClassification code 10060690Term: Traumatic brain injurySystem Organ Class: 10022117 - Injury, poisoning and procedural complicationsEUCTR2022-003382-38-ROFSNANO05012022440
招募中
3 期
Efficacy of Cerebrolysin Treatment as an add-on Therapy to Mechanical Thrombectomy in Acute Ischemic Stroke.Stroke, IschemicStroke, AcuteStroke SequelaeNCT04904341Military Institute od Medicine National Research Institute50