Management of hyperglycaemia and platelet activity in patients with acute coronary syndrome

Completed

• Conditions: Acute coronary syndrome; Circulatory System

• Registration Number: ISRCTN35708451
• Lead Sponsor: Hospital Clínico San Carlos, Instituto Cardiovascular (Spain)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-01-11
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

Consecutive patients admitted to the Coronary Care Unit with ACS and hyperglycaemia will be enrolled if they meet the following criteria:
1. Chest pain in the 24 hours previous to their inclusion
2. Older than 18 years
3. Written informed consent
4. Participant must have one of the following:
4.1. ST segment elevation of at least 0.1 mV in two or more adjacent leads
4.2. New onset left bundle branch block
4.3. ST segment depression of at least 0.1 mV in two or more adjacent leads
4.4. Markers of myocardial necrosis (cardiac troponin I above normal levels)
5. Participants must have one of the following:
5.1. Known diabetes and glycaemia greater than 120 mg/dl (6.66 mmol/l) on admission
5.2. No diagnosis of diabetes and glycaemia greater than 160 mg/dl (8.88 mmol/l) on admission
5.3. No diagnosis of diabetes and glycaemia between 120 to 160 mg/dl at admission, and greater than 120 mg/dl one hour later

Exclusion Criteria

1. Women of childbearing age
2. Inclusion in another clinical trial
3. Life expectancy of less than 1 year
4. High probability of loss on follow-up
5. Unclear origin of chest pain
6. Patients with scheduled percutaneous coronary interventions with complications during the procedure and are admitted to the Coronary Unit, but without chest pain in the last 24 hours
7. Patients on mechanical ventilation
8. Ethical barriers (e.g., patients who are not fluent in Spanish, relatives of investigators)
9. Glycaemia greater than 400 mg% (22.20 mmol/l) on admission

Study & Design

• Study Type: Interventional
• Study Design: Not specified