Reproducibility of measurement of skeletal muscle tissue oxygenation in patients with chronic heart failure.

Recruiting

• Conditions: Chronic Heart Failure, Exercise intolerance, Skeletal muscle impairment.Chronisch hartfalen, inspanningsintolerantie, skeletspierbeperking

• Registration Number: NL-OMON19931
• Lead Sponsor: Maxima Medical Center

Brief Summary

Kemps HM, Schep G, Zonderland ML, Thijssen EJ, De Vries WR, Wessels B, Doevendans PA, Wijn PF. Are oxygen uptake kinetics in chronic heart failure limited by oxygen delivery or oxygen utilization? International journal of cardiology 142: 138-44, 2010.<br> Kemps HMC, Prompers JJ, Wessels B, de Vries WR, Zonderland ML, Thijssen EJM, Nicolay K, Schep G, Doevendans AFM. Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O2 delivery than O2 utilization. Clin.Sci.(Lond) 118: 203-210, 2010.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

1. Written informed consent;

2. Systolic heart failure secondary to ischemic or dilated cardiomyopathy;

Exclusion Criteria

1. Myocardial infarction or unstable angina less than 3 months prior to inclusion;

2. Clinical signs of decompensated heart failure;

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference (paired T-test when normally distributed) and agreement (intra-class correlation coefficients, limits of agreement and coefficients of variation) of the rate of muscle deoxygenation at exercise onset between two days (rate of decrease of muscle tissue saturation index expressed as MRT-TSI).

Secondary Outcome Measures

Name	Time	Method
Difference (independent T-test when normally distributed) of VO2 kinetics (rate of increase in VO2 after onset of submaximal exercise expressed as ô-VO2) and NIRS kinetics (MRT-TSI) between healthy subjects and CHF patients during the first submaximal exercise test.