A STUDY TO COMPARE THE EFFECTS BETWEEN DEXMEDETOMIDINE AND ESMOLOL TO REDUCE THE BLOOD PRESSURE, INTURN DECREASING THE BLOOD LOSS DURING SURGERIES OF NOSE AND TO FIND OUT WHICH AMONGST THESE TWO IS SAFE AND BETTER.

Not yet recruiting

• Conditions: Acquired deformity of nose,

• Registration Number: CTRI/2020/07/026711
• Lead Sponsor: SAPTHAGIRI INSTITUTE OF MEDICAL SCIENCES

Brief Summary

COMPARATIVE STUDY OF EFFECT OF LOW DOSE DEXMEDETOMIDINE INFUSION WITH THAT OF LOW DOSE ESMOLOL INFUSION ON INTRAOPERATIVE HEMODYNAMICS, ANESTHETIC REQUIREMENTS AND RECOVERY PROFILE IN PATIENTS UNDERGOING NASAL SURGERIES – A DOUBLE BLIND RANDOMIZED STUDY IN TERTIARY CARE CENTRE.

Good surgical field visibility is one of the basic prerequisites for precise and safe otorhinolaryngological operations. Controlled hypotension (CH) at a moderate level (mean blood pressure –MAP 65-70mmHg) is often preferred during nasal surgical procedures such as Functional Endoscopic Sinus Sugery (FESS) and septorhinoplasty in order to reduce hemorrhaging and thus reduce complications via improved surgical field visibility.



This study is primarily designed to evaluate and compare the effect of the infusion of low dose esmolol with that of low dose dexmedetomidine on the intraoperative hemodynamic profile, blood loss during nasal surgery and emergence from anesthesia.



Objectives of the study:

1) To compare the efficacy of low dose dexmedetomidine infusion with that of low dose esmolol infusion on the intraoperative hemodynamic profile, blood loss during surgery and emergence from anesthesia.

2) To evaluate the effect of these infusions on intraoperative anesthetic and analgesic requirements.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-07-20
• Study Start: 2020-07-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1.American society of anaesthesiologists (ASA) grade 1 and 2 patients aged 20-50 years undergoing nasal surgeries under general anaesthesia 2.Patients willing to give consent.

Exclusion Criteria

1.Pregnant women 2.Allergy to the study drugs 3.Morbidly obese patients with body mass index (BMI) >30 kg/m2.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the efficacy of low dose dexmedetomidine infusion with that of low dose esmolol infusion on the intraoperative hemodynamic profile, blood loss during surgery and emergence from anesthesia.	Maintaining Mean arterial pressure of 65-70mmHg throughout the surgery and measuring once every 5 minutes for the initial 20 minutes and once every 10 minutes thereafter

Secondary Outcome Measures

Name	Time	Method
To evaluate the effect of these infusions on intraoperative anesthetic and analgesic requirements.	Concentration of sevoflurane in % recorded once every 5 minutes for initial 20 minutes and once every 10 minutes thereafter

Trial Locations

Locations (1)

SAPTHAGIRI INSTITUTE OF MEDICAL SCIENCES; 🇮🇳 Bangalore, KARNATAKA, India

SAPTHAGIRI INSTITUTE OF MEDICAL SCIENCES

🇮🇳Bangalore, KARNATAKA, India

Dr Shridevi Gudi

Principal investigator

8147402996

sggudi2908@gmail.com