CB1R in Synthetic Psychoactive Cannabinoids
- Conditions
- Drug Dependence
- Interventions
- Other: [11-C]OMAR
- Registration Number
- NCT03539575
- Lead Sponsor
- Yale University
- Brief Summary
The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 15
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Synthetic Psychoactive Cannabinoid Users [11-C]OMAR Synthetic Psychoactive Cannabinoid dependent subjects who are frequent spice/K2 users will receive the radiotracer \[11-C\]OMAR.
- Primary Outcome Measures
Name Time Method Positron Emission Tomography (PET Imaging) Change in CB1R availability from baseline throughout one test day CB1R availability using \[11-C\]OMAR PET imaging Change in CB1R availability (e.g. volume distribution).
- Secondary Outcome Measures
Name Time Method CogState Battery Change in CB1R availability from baseline throughout one test day 2. Changes in Cognition during withdrawal using a computerized battery Changes in cognitive functions such as attention, memory, motor functioning, and processing speed.
Electroencephalogram Change in CB1R availability from baseline throughout one test day 3. Changes in brain rhythms measured by Electroencephalography Changes in electroencephalographic (EEG) brain rhythms related to information processing.
Trial Locations
- Locations (1)
Connecticut Mental Health Center
🇺🇸New Haven, Connecticut, United States