Influence of Different Forms of Exercise Training in Patients With Coronary Artery Disease
- Conditions
- Coronary Artery Disease
- Interventions
- Other: land-based exercise trainingOther: water-based exercise training
- Registration Number
- NCT02831829
- Lead Sponsor
- University Medical Centre Ljubljana
- Brief Summary
The aim of the study is to compare the effect of water-based and land-based exercise training, and usual care (no exercise training) in patient with coronary artery disease, on exercise capacity, vascular function, arrhythmogenic potential and cardiac autonomic function, and markers of neurohormonal activity, activated hemostasis and inflammation.
- Detailed Description
Swimming and other water-based physical activities represent an effective form of aerobic-dynamic exercise. However, existing guidelines mainly advise caution when recommending water-based activities to patients with coronary artery disease. To date, safety and efficacy of short-term water-based exercise in patients with coronary artery diseases have only scarcely been addressed.
Cardiovascular rehabilitation is an integral part of management after a myocardial infarction or coronary procedure. Most rehabilitation programs are exercise-based, since the beneficial effects of physical activity undisputed, and corroborated by a large body of evidence.
Most rehabilitation programs are exercise-based, since the beneficial effects of physical activity undisputed, and corroborated by a large body of evidence.
Research has mainly been focused on the impact assessment of the standard forms of physical training, they studied various forms of physical exercise, mainly land-based. No previous study has reported on the effect of exercise in water as an integral element of standard cardiac rehabilitation in coronary patients on exercise capacity, vascular function, arrhythmogenic potential and cardiac autonomic function, and markers of neurohormonal activity, activated hemostasis and inflammation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- patients with coronary artery disease after myocardial infarction or myocardial revascularization (percutaneous coronary procedure or surgical revascularization)
- unstable coronary artery disease, ejection fraction of the left ventricle of 40% or less, heart valve defect that dictate specific treatment, condition after valve replacement, heart rhythm disorders, the presence of a permanent pacemaker, contraindications to exercise, inability to perform exercise testing, mental retardation, severe anemia, obstructive/restrictive lung disease severe degree, recent thrombo embolic events, age over 80 years.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Land-based exercise training group land-based exercise training Patients randomized to the "land-based exercise training group" will undergo exercise training which will include two aerobic and calisthenic exercise session per day, six days of a week, lasting 30 minutes Water-based exercise training group water-based exercise training Intervention: Patients randomized to the "water-based exercise training group" will undergo water-based exercise training. The immersed exercise will include two session of aerobic (water-based) and calisthenic exercise per day, six days of a week, each lasting 30 minutes.
- Primary Outcome Measures
Name Time Method Change of maximal oxygen consumption during cardiopulmonary bicycle exercise testing 14 days
- Secondary Outcome Measures
Name Time Method Change of arrhythmogenic potential estimated by high resolution ECG 14 days Change in heart rate variability, estimated by high resolution ECG 14 days Change of N terminal - proBNP serum concentration value , measured in ng/l 14 days Change of the D-dimer serum concentration value, measured in microg/l 14 days Change of flow-mediated dilation of brachial artery measured in % 14 days Change of the C-reactive protein serum concentration value, measured in g/l 14 days Change in fibrinogen serum concentration value, measured in g/l 14 days Change of from-the-questionnaire-obtained quality of life, measured in points 14 days
Trial Locations
- Locations (2)
Terme Krka
🇸🇮Novo Mesto, Slovenia
University medical center Ljubljana
🇸🇮Ljubljana, Slovenia