CTRI/2012/01/002384RecruitingPhase 4
Effect of nebivolol on endothelial dysfunction in coronary artery disease patients - NEDCAD
Trial Snapshot
- Phase
- Phase 4
- Status
- Recruiting
- Sponsor
- JIPMER
- Enrollment
- 80
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
Inclusion Criteria
- •1.Age - 18-75 years
- •2.Either sex
- •3.Angiographically proven coronary artery stenosis with >50% block in atleast one of the major arteries or History of acute coronary syndrome
- •4. Known case of Hypertension
Exclusion Criteria
- •1.Patients with history of acute coronary syndrome in the preceding three months.
- •2.Patients already on nebivolol for BP control
- •3.Uncontrolled hypertension with SBP > 180mm Hg or DBP >90mmHg
- •4.Patients with left ventricular ejection fraction <35%
- •5.Patients with coexisting medical illnesses which can interfere with assessment of outcomes
- •6.Known history of hypersensitivity reaction to nebivolol
- •7.Pregnant women and lactating women
- •8.Patients having coexisting illness which are a contra-indication to beta blocker therapy such as asthma, sick sinus syndrome, peripheral vascular disease, variant angina.
- •9.Marked dyslipidemia
- •10.Patients unwilling to participate in the study
- •11.Past history of liver disease, known case of alcohol abuse, or Elevated liver enzymes defined as ALT, AST or ALP greater than thrice the upper limit of normal.
Investigators
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