The impact of short-term bed-rest on skeletal muscle mass and insulin sensitivity in healthy, young me

Completed

Conditions: muscle metabolism
disuse atrofie
10000546
10028302

Registration Number: NL-OMON41776

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

- Male
- Aged from 18-35 years
- 18.5 < BMI < 30 kg/m2
- Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 60 minutes)

Exclusion Criteria

- Smoking
- Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
- Hypertension (according to WHO criteria) [45] and/or cardiovascular disease
- Any back/leg/knee/neck/postural complaints
- Use of any prescribed medication
- Type 2 diabetes mellitus
- Any family history of thrombosis
- All co-morbidities interacting with mobility and muscle metabolism of the lower limbs
(e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
- Myocardial infarction within the last 3 years
- Use of anti-coagulants
- A history of deep vein thrombosis (DVT) in the leg

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quadriceps muscle cross sectional area (CSA) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Whole body insulin sensitivity, whole body lean mass, leg lean mass, lower back<br /><br>muscle CSA, muscle strength, type I and II muscle fiber CSA and SC content,<br /><br>mRNA and protein expression of key genes involved in the regulation of muscle<br /><br>mass.</p><br>