Comparison of novel assays for the molecular detection and quantification of bacteria in patients with bloodstream infections: COMBI study
Recruiting
- Conditions
- SepsisBacteraemia/ bacteremiaMolecular diagnosis bacteria in blood
- Registration Number
- NL-OMON21547
- Lead Sponsor
- VU University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Age >= 18 years ;
-Bacteraemia with at least one blood culture with growth of Gram-negative bacteria or Gram-positive cocci in chain observed with microscopy;
Exclusion Criteria
-Blood culture obtained >48 hours;
-Intravenous antibiotic therapy >48 hours;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary objectives: <br /><br>1.To determine the diagnostic performance of five molecular assays for the detection of bacteraemia in patients. <br /><br>2.To evaluate the relationship between the bacterial DNA load (BDL), quantitative culture and culture time-to-positivity in patients with bacteraemia.
- Secondary Outcome Measures
Name Time Method Secondary objective: <br /><br>1.To assess the putative applicability of the molecular assays in routine molecular diagnostics with regard to costs, hands on time and difficulty of the protocol in routine use.