Sciatic Nerve Stiffness Using Two-Sequences of Lower Limb Neurodynamic Testing: A Shear Wave Elastography Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Shear Wave Velocity (SWV) measured in meters per second (m/s)
研究概览
简要总结
The purposes of the study are:
- To measure differences in Sciatic nerve (SN) stiffness using shear-wave elastography (SWE) during two movement sequences of the lower limb neurodynamic test (LLNT) in low back pain with sciatica.
- To measure differences in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test in control group.
- To compare difference in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test between low back pain patients with sciatica and control group.
详细描述
As peripheral nerves can exhibit regional variations in their anatomy and mechanical properties, investigating the response of different nerve segments to different loading patterns based on the order of joint movement will provide a better understanding of nerve biomechanics during neurodynamic testing.
This may help optimize the lower limb neurodynamic test (LLNT) application for different pathological situations and potentially increase its diagnostic capacity to detect localized alterations in a specific nerve segment such as sciatica.
Ultrasonography does not have the sensitivity required to detect all forms of peripheral nerve disorders and fails to provide information about nerve mechanical properties such as stiffness.
By using neurodynamic sequencing, clinicians may direct neural stress toward targeted areas suspected of involvement and, at the same time, perform the test with reduced load on more remote nerve segments. The ability to modify neural load distribution during the LLNT could play an interesting role in differential diagnosis, when symptoms present similar characteristics but have different regional origin.
There is a gap in the literature concerning the measurement of (SWV) of sciatic nerve during LLNT proximal (LLNT-PROX) to distal and from distal (LLNT_DIST) to proximal sequences of LLNT.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Thirty participants ranging in age from 25 to 40 years from both genders with a diagnosis of low back pain with radiating leg pain and thirty control group.
- •The main symptoms are low back pain with unilateral leg pain(sciatica) for 3-12 months for group A.
- •Patients with lumbar disc herniation (L4-5) with diagnostic imaging as MRI for group A.
- •Positive straight leg raising are considered for inclusion in the study for group A.
- •Control group must be free from any symptoms of nerve irritation or compression, with normal neurological examination findings, including reflexes, sensation, negative straight leg raising and motor strength.
排除标准
- •Diabetes mellitus.
- •Any type of polyneuropathy
- •Trauma of lumbar spine
- •Previous history of back surgery
- •Piriformis syndrome.
- •Participants with conditions that reduce image quality on US imaging (thick gluteal subcutaneous fat tissue.
- •Hip joint prosthesis.
- •Professional athletes (Neto et al., 2024).
- •Skin infection
结局指标
主要结局
Shear Wave Velocity (SWV) measured in meters per second (m/s)
时间窗: 20 minutes, During a single assessment session at baseline
Quantitative measurement of sciatic nerve stiffness during two different movement sequences of the Lower Limb Neurodynamic Test (LLNT). Higher SWV values indicate increased nerve stiffness.
次要结局
未报告次要终点
研究者
Manar Fawzy Mohamed
Principal Investigator
Cairo University