Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 40
- Locations
- 2
- Primary Endpoint
- DTI parameters in cervical spinal cord
Study Overview
Brief Summary
This study aims at evaluating spinal cord structure using diffusion tensor imaging in patients with cervical spondylosis.
Detailed Description
Diffusion tensor imaging (DTI) of the cervical spinal cord will be performed in patients with cervical spondylosis with varying degrees of symptoms and in healthy control subjects. Fibre tracking of main spinal tracts will be performed. Regions of interest will also be identified. Diffusion parameters will be extracted. This will allow quantification of degree of damage in of the spinal cord. The findings will be related to motor function measures and comprehensive clinical tests of sensory and motor function.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18-70 years old
- •Sufficiently cooperative
- •Cognitively understands study and implications
- •Signed informed consent
- •Symptomatic cervical spondylosis
Exclusion Criteria
- •MRI contraindications (e.g., pacemaker, metal implants, claustrophobia)
- •Previous pathology that would impact behavioural measures
- •Anxiety and poor cooperation
- •Previous neurological condition
- •Pregnancy
Arms & Interventions
Patients
Intervention: DTI - Diffusor Tensor Imaging (Device)
Healty volunteers
Intervention: DTI - Diffusor Tensor Imaging (Device)
Outcomes
Primary Outcomes
DTI parameters in cervical spinal cord
Time Frame: 3 weeks
Secondary Outcomes
- Clinical data, i.e., Muscle testing, sensory testing, reflexes, spasticity, and Motor function (dexterity test), grip strength(3 weeks)