Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- DTI parameters in cervical spinal cord
研究概览
简要总结
This study aims at evaluating spinal cord structure using diffusion tensor imaging in patients with cervical spondylosis.
详细描述
Diffusion tensor imaging (DTI) of the cervical spinal cord will be performed in patients with cervical spondylosis with varying degrees of symptoms and in healthy control subjects. Fibre tracking of main spinal tracts will be performed. Regions of interest will also be identified. Diffusion parameters will be extracted. This will allow quantification of degree of damage in of the spinal cord. The findings will be related to motor function measures and comprehensive clinical tests of sensory and motor function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-70 years old
- •Sufficiently cooperative
- •Cognitively understands study and implications
- •Signed informed consent
- •Symptomatic cervical spondylosis
排除标准
- •MRI contraindications (e.g., pacemaker, metal implants, claustrophobia)
- •Previous pathology that would impact behavioural measures
- •Anxiety and poor cooperation
- •Previous neurological condition
- •Pregnancy
研究组 & 干预措施
Patients
干预措施: DTI - Diffusor Tensor Imaging (Device)
Healty volunteers
干预措施: DTI - Diffusor Tensor Imaging (Device)
结局指标
主要结局
DTI parameters in cervical spinal cord
时间窗: 3 weeks
次要结局
- Clinical data, i.e., Muscle testing, sensory testing, reflexes, spasticity, and Motor function (dexterity test), grip strength(3 weeks)