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临床试验/NCT05079945
NCT05079945已完成不适用

Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas

Hospices Civils de Lyon2 个研究点 分布在 1 个国家目标入组 49 人开始时间: 2022年2月5日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
49
试验地点
2
主要终点
Spinal tracts differentiation and identification

研究概览

简要总结

Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs.

The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patient> 18 years old
  • Healthy volunteer
  • Social insured in France
  • Patient who signed the informed consent of the study

排除标准

  • Medical or surgical history of disease that may affect the central nervous system, or the spine
  • History of spine or spinal cord trauma.
  • Spinal osteoarthritis which can lead to a medullary hyper signal.
  • Contraindication to MRI: claustrophobia, pace-maker, defibrillator, metallic foreign bodies, etc.
  • Subjects benefiting from legal protection (curatorship, guardianship or safeguard of justice).
  • Pregnant and / or breastfeeding woman.

结局指标

主要结局

Spinal tracts differentiation and identification

时间窗: date of Tractography procedure (DTI MRI)

Percentage of complete tracts identified among healthy volunteer

次要结局

  • Spinal cord Tracts Atlas(12 months (end of recruitment and exams))

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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