Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- Spinal tracts differentiation and identification
研究概览
简要总结
Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs.
The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patient> 18 years old
- •Healthy volunteer
- •Social insured in France
- •Patient who signed the informed consent of the study
排除标准
- •Medical or surgical history of disease that may affect the central nervous system, or the spine
- •History of spine or spinal cord trauma.
- •Spinal osteoarthritis which can lead to a medullary hyper signal.
- •Contraindication to MRI: claustrophobia, pace-maker, defibrillator, metallic foreign bodies, etc.
- •Subjects benefiting from legal protection (curatorship, guardianship or safeguard of justice).
- •Pregnant and / or breastfeeding woman.
结局指标
主要结局
Spinal tracts differentiation and identification
时间窗: date of Tractography procedure (DTI MRI)
Percentage of complete tracts identified among healthy volunteer
次要结局
- Spinal cord Tracts Atlas(12 months (end of recruitment and exams))
