Australian Hepatitis and Risk Survey in Prisons

Recruiting

• Conditions: Hepatitis B; Hepatitis C; HIV Infections
• Interventions: Diagnostic Test: Point-of-care hepatitis C antibody test; Diagnostic Test: Point-of-care hepatitis C RNA test; Diagnostic Test: Point-of-care hepatitis B surface antibody test; Diagnostic Test: Point-of-care hepatitis B surface antigen test; Diagnostic Test: Point-of-care HIV antibody test; Behavioral: Interview-style survey

• Registration Number: NCT05839522
• Lead Sponsor: Kirby Institute

Brief Summary

The Australian Hepatitis and risk survey in prisons (AusHep) is a national prison-based blood-borne virus (BBV) surveillance study. This biobehavioural survey involves point-of-care testing for hepatitis C (HCV) antibodies and RNA (if antibody positive), hepatitis B surface antigens, hepatitis B surface antibodies, and HIV surface antibodies, and an interview-style survey on prior testing and treatment history and engagement in risk behaviours. The study will recruit approximately 2400 prisoner participants from 25 representative prisons across Australia, annually.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-27
• Study First Submitted: 2023-03-06
• Status Verified: 2023-04
• Study First Submitted QC: 2023-04-20
• Last Update Submitted: 2023-04-20
• Primary Completion: 2023-05-01
• Study Completion: 2023-05-01
• Study First Posted: 2023-05-03
• Last Update Posted: 2023-05-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2400

Inclusion Criteria

• Any remandee or sentenced prisoner who has provided informed consent is eligible to participate in the study.

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Exclusion Criteria

• Individuals who are unable or unwilling to provide consent or abide by the requirements of the study, as assessed by the trained nurses. Some individuals may be considered unable to provide consent or abide by the requirements of the study if they are:

  • Too mentally unwell to provide consent
  • Profoundly intellectually impaired
  • Unable to speak English and comprehend the survey.

Those excluded from participating in the study will be referred to the local prison clinic service for standard of care.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Persons in custody in Australia	Point-of-care HIV antibody test	Representative sample of 2400 people in prison from 25 representative prisons in Australia will participate in a biobehavioural survey involving point-of-care testing for HCV antibodies and RNA (if antibody positive), HBV surface antigens and antibodies, and HIV antibodies, and an interview-style survey.
Persons in custody in Australia	Point-of-care hepatitis C RNA test	Representative sample of 2400 people in prison from 25 representative prisons in Australia will participate in a biobehavioural survey involving point-of-care testing for HCV antibodies and RNA (if antibody positive), HBV surface antigens and antibodies, and HIV antibodies, and an interview-style survey.
Persons in custody in Australia	Point-of-care hepatitis B surface antigen test	Representative sample of 2400 people in prison from 25 representative prisons in Australia will participate in a biobehavioural survey involving point-of-care testing for HCV antibodies and RNA (if antibody positive), HBV surface antigens and antibodies, and HIV antibodies, and an interview-style survey.
Persons in custody in Australia	Interview-style survey	Representative sample of 2400 people in prison from 25 representative prisons in Australia will participate in a biobehavioural survey involving point-of-care testing for HCV antibodies and RNA (if antibody positive), HBV surface antigens and antibodies, and HIV antibodies, and an interview-style survey.
Persons in custody in Australia	Point-of-care hepatitis C antibody test	Representative sample of 2400 people in prison from 25 representative prisons in Australia will participate in a biobehavioural survey involving point-of-care testing for HCV antibodies and RNA (if antibody positive), HBV surface antigens and antibodies, and HIV antibodies, and an interview-style survey.
Persons in custody in Australia	Point-of-care hepatitis B surface antibody test	Representative sample of 2400 people in prison from 25 representative prisons in Australia will participate in a biobehavioural survey involving point-of-care testing for HCV antibodies and RNA (if antibody positive), HBV surface antigens and antibodies, and HIV antibodies, and an interview-style survey.

Primary Outcome Measures

Name	Time	Method
The prevalence of HCV in Australian prisons	1 Year	This is estiamted by perfroming the HCV antibody test and HCV RNA viral load test on a representative prison population.
The prevalance of HBV in Australian prisons	1 year	This is estimated by performing the HBV surface antigen test on a respresentative prison population
The prevalance of HIV in Australian prisons	1 year	This is estimated by performing the HIV antibody test on a respresentative prison population.

Secondary Outcome Measures

Name	Time	Method
The factors associated with HCV and HBV infection investigated by the bio-behavioural survey.	1 Year
The proportion of individuals who are engaged in each step of HBV and HCV care cascades	1 Year	This is estimated by conducting the bio-behavioural survey.
The prevalence of risk behaviours and harm reduction access	1 Year	The risk behavrious and harm reduction measures include injecting and non-injecting drug use, high risk injecting practices, sexual risk behaviours, tattooing; and bleach or opioid substitution therapy (OST) uptake. This is estimated by conducting the bio-behavioural survey.
The factors associated with engaging in each step of HCV and HBV care cascades and HBV vaccination investigated by the bio-behavioural survey.	1 Year

Trial Locations

Locations (24)

Bandyup Women's Prison; 🇦🇺 West Swan, Western Australia, Australia

Alice Springs Correctional Centre; 🇦🇺 Alice Springs, Northern Territory, Australia

Alexander Maconochie Centre; 🇦🇺 Hume, Australian Capital Territory, Australia

Risdon Maximum Prison; 🇦🇺 Risdon Vale, Tasmania, Australia

Mary Hutchinson Women's Prison; 🇦🇺 Risdon Vale, Tasmania, Australia

Bathurst Correctional Complex; 🇦🇺 Bathurst, New South Wales, Australia

John Morony Correctional Complex; 🇦🇺 Berkshire Park, New South Wales, Australia

Cessnock Correctional Centre; 🇦🇺 Cessnock, New South Wales, Australia

Mid North Coast Correctional Centre; 🇦🇺 Kempsey, New South Wales, Australia

Silverwater Women's Correctional Centre; 🇦🇺 Silverwater, New South Wales, Australia

South Coast Correctional Centre; 🇦🇺 Nowra, New South Wales, Australia

Wellington Correctional Centre; 🇦🇺 Wuuluman, New South Wales, Australia

Borallon Training and Correctional Centre; 🇦🇺 Ironbark, Queensland, Australia

Darwin Correctional Centre; 🇦🇺 Howard Springs, Northern Territory, Australia

Brisbane Women's Correctional Centre; 🇦🇺 Ironbark, Queensland, Australia

Townsville Correctional Centre; 🇦🇺 Townsville, Queensland, Australia

Wolston Correctional Centre; 🇦🇺 Ironbark, Queensland, Australia

Adelaide Women's Prison; 🇦🇺 Northfield, South Australia, Australia

Mobilong Prison; 🇦🇺 Murray Bridge, South Australia, Australia

Yatala Labour Prison; 🇦🇺 Northfield, South Australia, Australia

Bunbury Regional Prison; 🇦🇺 Bunbury, Western Australia, Australia

Ron Barwick Minimum Security Prison; 🇦🇺 Risdon Vale, Tasmania, Australia

Casuarina Prison; 🇦🇺 Casuarina, Western Australia, Australia

Roebourne Regional Prison; 🇦🇺 Roebourne, Western Australia, Australia