A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)
- Conditions
- Antineoplastic AgentsSteroid Synthesis InhibitorsCytochrome P-450PrednisoloneNeoplasm MetastasisUrogenital NeoplasmsAntineoplastic Agents, HormonalHormones, Hormone Substitutes, and Hormone AntagonistsCyclin-Dependent Kinase 4Hormones
- Interventions
- Registration Number
- NCT05288166
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse. Participation may last approximately 60 months.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Male
- Target Recruitment
- 900
-
Adenocarcinoma of the prostate (as the predominant histology)
-
High-risk metastatic hormone-sensitive prostate cancer. High risk is defined as:
- Greater than or equal to (≥)4 bone metastases by bone scan and/or
- ≥1 visceral metastases by computed tomography or magnetic resonance imaging
-
Must have initiated androgen deprivation therapy (ADT) with luteinizing hormone-releasing hormone (LHRH) agonist/antagonist or bilateral orchiectomy prior to randomization. Up to 3 months of ADT prior to randomization is permitted with or without first-generation anti-androgen.
-
Adequate organ function
-
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Prior treatment with abemaciclib or any other cyclin dependent kinase 4 and 6 (CDK4 & 6) inhibitor
- Development of metastatic prostate cancer in the context of castrate levels of testosterone
- Received any prior systemic therapy for metastatic prostate cancer (including investigational agents), except for ADT and first-generation anti-androgen
- Clinically significant cardiovascular disease as evidenced by myocardial infarction, arterial thrombotic events, or severe/unstable angina in the past 6 months, or New York Heart Association Class II to IV heart failure
- History of syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin, or sudden cardiac arrest. Chronic and hemodynamically stable atrial arrhythmia well-controlled on medical therapy is permitted
- Uncontrolled hypertension
- Clinically active or chronic liver disease, moderate/severe hepatic impairment
- Known untreated central nervous system (CNS) metastasis. Participants with a history of treated brain metastases are eligible if stable for at least 8 weeks prior to randomization and off corticosteroid for at least 2 weeks prior to randomization
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo + Abiraterone + Prednisone/Prednisolone Prednisone or Prednisolone Placebo + abiraterone + prednisone/prednisolone administered orally. Placebo + Abiraterone + Prednisone/Prednisolone Placebo for Abemaciclib Placebo + abiraterone + prednisone/prednisolone administered orally. Abemaciclib + Abiraterone + Prednisone/Prednisolone Prednisone or Prednisolone Abemaciclib plus (+) abiraterone + prednisone/prednisolone administered orally. Abemaciclib + Abiraterone + Prednisone/Prednisolone Abemaciclib Abemaciclib plus (+) abiraterone + prednisone/prednisolone administered orally. Abemaciclib + Abiraterone + Prednisone/Prednisolone Abiraterone Abemaciclib plus (+) abiraterone + prednisone/prednisolone administered orally. Placebo + Abiraterone + Prednisone/Prednisolone Abiraterone Placebo + abiraterone + prednisone/prednisolone administered orally.
- Primary Outcome Measures
Name Time Method Radiographic Progression-Free Survival (rPFS) Assessed by Investigator Randomization to radiographic progression or death from any cause (approximately 48 months) rPFS Assessed by Investigator
- Secondary Outcome Measures
Name Time Method rPFS Assessed by Blinded Independent Central Review (BICR) Randomization to radiographic progression or death from any cause (approximately 48 months) rPFS Assessed by BICR
Pharmacokinetics (PK): Mean Steady State Exposure of Abemaciclib Postdose Cycle 1 Day 1 through Predose Cycle 3 Day 1 (28 Day Cycles) PK: Mean steady state exposure of abemaciclib
Overall Survival (OS) Baseline to date of death due to any cause (approximately 60 months) OS
Time to Deterioration in Health-Related Quality of Life (HRQoL) Randomization to the date of HRQoL deterioration (approximately 48 Months) Measured by the Functional Assessment of Cancer Therapy-Prostate (FACT-P; Physical well-being and Prostate Cancer Subscale). The FACT-P is a 39-item self-reported questionnaire that assesses physical well-being (7 items), social/family well-being (7 items), emotional well-being (6 items), functional well-being (7 items), and additional prostate cancer specific concerns (12 items). All items are scored from 0 (not at all) to 4 (very much). The total FACT-P score ranges from 0-156, with higher scores representing a better quality of life.
Time to Pain Progression Randomization to pain progression (approximately 48 months) Measured by a combination of 2 scales, the Brief Pain Inventory Short Form (BPI-SF) Worst Pain Numeric Rating Scale (NRS) and the Analgesic Quantification Algorithm (AQA) scale. The BPI-SF Worst Pain NRS is a self-reported 11-item questionnaire on worst pain intensity on the past 24 hours. Score ranges from 0 (no pain) to 10 (pain as bad as you can imagine). The AQA scores analgesic use from 0 (minimum) to 7 (maximum).
Castration-resistant Prostate Cancer (CRPC)-free Survival Randomization to the earliest date of PSA or radiographic progression with a testosterone level of ≤50 nanogram/deciliter (ng/dL); or death from any cause (approximately 48 months) CRPC-free Survival
Trial Locations
- Locations (263)
AHN Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
🇲🇽Monterrey, Nuevo León, Mexico
TriState Urologic Services PSC Inc.
🇺🇸Cincinnati, Ohio, United States
Minnesota Oncology/Hematology PA
🇺🇸Minneapolis, Minnesota, United States
Urology San Antonio Research
🇺🇸San Antonio, Texas, United States
Sarah Cannon Research Institute
🇺🇸Nashville, Tennessee, United States
University of Colorado Anschutz Medical Campus
🇺🇸Aurora, Colorado, United States
Trakya University
🇹🇷Edirne, Turkey
Bacs-Kiskun Megyei Korhaz
🇭🇺Kecskemét, Bács-Kiskun, Hungary
Summit Cancer Care DBA Candler Medical Oncology Practice
🇺🇸Savannah, Georgia, United States
Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
🇦🇷San Juan, Argentina
Instituto de de Educação, pesquisa e Gestão em Saúde
🇧🇷Rio de Janeiro, Brazil
Millennium Oncology Research Clinic
🇺🇸Hollywood, Florida, United States
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
🇯🇵Nagoya, Aichi, Japan
Osaka Metropolitan University Hospital
🇯🇵Osaka, Japan
Genesis Cancer and Blood Institute
🇺🇸Hot Springs, Arkansas, United States
UCLA Hematology/Oncology - Santa Monica
🇺🇸Los Angeles, California, United States
The University of Arizona Cancer Center - North Campus
🇺🇸Tucson, Arizona, United States
Moores Cancer Center
🇺🇸La Jolla, California, United States
Arizona Oncology Associates, P.C. - HOPE
🇺🇸Prescott, Arizona, United States
MemorialCare Health System - Long Beach Medical Center
🇺🇸Long Beach, California, United States
Torrance Memorial Physician Network / Cancer Care
🇺🇸Torrance, California, United States
St. Bernards Medical Center
🇺🇸Jonesboro, Arkansas, United States
Highlands Oncology Group
🇺🇸Springdale, Arkansas, United States
Cancer and Blood Specialty Clinic
🇺🇸Los Alamitos, California, United States
PIH Health Hematology Medical Oncology
🇺🇸Whittier, California, United States
UCHealth Harmony
🇺🇸Fort Collins, Colorado, United States
Colorado West Healthcare System - Grand Valley Oncology
🇺🇸Grand Junction, Colorado, United States
UCHealth Memorial Hospital
🇺🇸Colorado Springs, Colorado, United States
Memorial Regional Hospital
🇺🇸Hollywood, Florida, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center
🇺🇸Miami, Florida, United States
Florida Cancer Specialists - South
🇺🇸Fort Myers, Florida, United States
USO-Rocky Mountain Cancer Center
🇺🇸Littleton, Colorado, United States
Dwight D Eisenhower Army Medical Center
🇺🇸Fort Gordon, Georgia, United States
Northeast Georgia Medical Center
🇺🇸Gainesville, Georgia, United States
Central Georgia Cancer Care
🇺🇸Macon, Georgia, United States
Chesapeake Urology
🇺🇸Towson, Maryland, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Reliant Medical Group
🇺🇸Worcester, Massachusetts, United States
Care Access - Clifton
🇺🇸Clifton, New Jersey, United States
Laura and Isaac Perlmutter Cancer Center
🇺🇸New York, New York, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
🇺🇸Mineola, New York, United States
Clinical Research Alliance
🇺🇸Westbury, New York, United States
Northwest Cancer Specialist
🇺🇸Tigard, Oregon, United States
MidLantic urology
🇺🇸Bala-Cynwyd, Pennsylvania, United States
Texas Oncology - Balcones
🇺🇸Austin, Texas, United States
Tennessee Oncology Chattanooga-SCRI
🇺🇸Chattanooga, Tennessee, United States
Parkland Health and Hospital System
🇺🇸Dallas, Texas, United States
Texas Oncology - Carrollton
🇺🇸Flower Mound, Texas, United States
Houston Methodist Hospital
🇺🇸Houston, Texas, United States
USO - Texas Oncology Gulf Coast
🇺🇸Sugar Land, Texas, United States
Baylor Scott & White Medical Center - Temple
🇺🇸Temple, Texas, United States
Huntsman Cancer Institute
🇺🇸Salt Lake City, Utah, United States
US Oncology Research Network
🇺🇸The Woodlands, Texas, United States
Texas Oncology - Longview Cancer Center
🇺🇸Tyler, Texas, United States
Instituto de Investigaciones Clínicas Mar del Plata
🇦🇷Mar del Plata, Buenos Aires, Argentina
Asociación de Beneficencia Hospital Sirio Libanés
🇦🇷Buenos Aires, Buenos Air, Argentina
Oncology and Hematology Associates of Southwest Virginia Inc
🇺🇸Roanoke, Virginia, United States
Centro de Investigaciones Metabólicas (CINME)
🇦🇷Ciudad Autónoma de Buenos Aire, Buenos Air, Argentina
Investigaciones Clinicas Moleculares (ICM)
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Fundación Cenit Para La Investigación En Neurociencias
🇦🇷Caba, Ciudad Autónoma De Buenos Aire, Argentina
Centro Medico Privado CEMAIC
🇦🇷Capital, Córdoba, Argentina
Centro Oncologico Korben
🇦🇷Buenos Aires, Argentina
St Vincent's Hospital
🇦🇺Melbourne, Victoria, Australia
Fundación Respirar
🇦🇷Buenos Aires, Argentina
Centro Urológico Profesor Bengió
🇦🇷Córdoba, Argentina
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Macquarie University
🇦🇺Macquarie University, New South Wales, Australia
Coffs Harbour Health Campus
🇦🇺Coffs Harbour, New South Wales, Australia
Instituto Médico Río Cuarto
🇦🇷Río Cuarto, Córdoba, Argentina
Clinica Viedma
🇦🇷Viedma, Río Negro, Argentina
Icon Cancer Centre South Brisbane
🇦🇺South Brisbane, Queensland, Australia
Tasman Oncology Research
🇦🇺Southport, Queensland, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Monash Health
🇦🇺Clayton, Victoria, Australia
Barwon Health
🇦🇺Geelong, Victoria, Australia
Epworth Freemasons
🇦🇺Richmond, Victoria, Australia
Nucleo de Oncologia da Bahia
🇧🇷Salvador, Bahia, Brazil
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
🇧🇷Fortaleza, Ceará, Brazil
Onze Lieve Vrouw Ziekenhuis Aalst
🇧🇪Aalst, Oost-Vlaanderen, Belgium
UZ Gent
🇧🇪Gent, Oost-Vlaanderen, Belgium
AZ Groeninge Campus Kennedylaan
🇧🇪Kortrijk, West-Vlaanderen, Belgium
CHU UCL Namur/Site Sainte Elisabeth
🇧🇪Namur, Belgium
Centro Avançado de Tratamento Oncológico- CENANTRON
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Centro Integrado de Oncologia de Curitiba
🇧🇷Curitiba, Paraná, Brazil
Instituto de Oncologia Saint Gallen
🇧🇷Santa Cruz do Sul, Rio Grande Do Sul, Brazil
Hospital São Lucas da PUCRS
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
🇧🇷Barretos, São Paulo, Brazil
Hospital de Cancer de Londrina
🇧🇷Londrina, Paraná, Brazil
Instituto do Cancer Arnaldo Vieira de Carvalho
🇧🇷São Paulo, Brazil
Clínica de Oncologia Reichow
🇧🇷Blumenau, Santa Catarina, Brazil
Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
Beijing Hospital
🇨🇳Beijing, Beijing, China
Icesp - Instituto Do Câncer Do Estado de São Paulo
🇧🇷São Paulo, Brazil
Núcleo de Pesquisa Clínica da Rede São Camilo
🇧🇷São Paulo, Brazil
Afflilated Hospital of Bengbu Medical College
🇨🇳Bengbu, Anhui, China
Second Affiliated hospital of Anhui Medical University
🇨🇳Hefei, Anhui, China
Wannan Medical College Yijishan Hospital
🇨🇳Wuhu, Anhui, China
Peking University First Hospital
🇨🇳Beijing, Beijing, China
Sun Yat-Sen University Cancer Centre
🇨🇳Guangzhou, Guangdong, China
Wuhan Union Hospital
🇨🇳Wuhan, Hubei, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
Southern Medical University Nanfang Hospital
🇨🇳Guangzhou, Guangdong, China
Tongji Hospital Tongji Medical,Science & Technology
🇨🇳Wuhan, Hubei, China
Hunan Provincial People's Hospital
🇨🇳ChangSha, Hunan, China
Xiangya Hospital Central South University
🇨🇳Changsha, Hunan, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
Northern Jiangsu People's Hospital
🇨🇳Yangzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Jilin Cancer Hospital
🇨🇳Changchun, Jilin, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Huadong Hospital Affiliated to Fudan University
🇨🇳Shanghai, Shanghai, China
Shanghai Tenth People's Hospital
🇨🇳Shanghai, Shanghai, China
The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
Yantai Yuhuangding Hospital
🇨🇳Yantai, Shandong, China
West China Hospital of Sichuan University
🇨🇳ChengDu, Sichuan, China
Nanchong Central Hospital
🇨🇳Nanchong, Sichuan, China
Tianjin Medical University Cancer Institute and Hospital
🇨🇳Tianjin, Tianjin, China
The Second Hospital of Tianjin Medical University
🇨🇳Tianjin, Tianjin, China
The First Affiliated Hospital, Zhejiang University
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Provincial People's Hospital
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Ningbo First Hospital
🇨🇳Ningbo, Zhejiang, China
Nemocnice Horovice
🇨🇿Horovice, Beroun, Czechia
Masarykuv onkologicky ustav
🇨🇿Brno, Brno-město, Czechia
Fakultni Nemocnice u sv. Anny v Brne
🇨🇿Brno, Jihomoravský Kraj, Czechia
Oblastni nemocnice Pribram
🇨🇿Pribram, Příbram, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿PRague, Praha 10, Czechia
Fakultni Thomayerova nemocnice
🇨🇿Prague, Praha 4, Czechia
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Urocentrum Praha
🇨🇿Prague, Czechia
Hôpital privé du Confluent SAS
🇫🇷Nantes, Loire-Atlantique, France
Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan
🇫🇷Brest, Bretagne, France
Polyclinique De Blois
🇫🇷La Chaussée-Saint-Victor, Centre, France
Centre Georges François Leclerc
🇫🇷Dijon, Côte-d'Or, France
CHU Besançon
🇫🇷Besançon, Doubs, France
Centre de Cancérologie du Grand Montpellier
🇫🇷Montpellier, Languedoc-Roussillon, France
Institut de Cancérologie de l'Ouest
🇫🇷Saint Herblain, Loire-Atlantique, France
Hôpital Européen Georges Pompidou
🇫🇷Paris, France
Institut Paoli-Calmettes
🇫🇷Marseille, Provence-Alpes-Côte-d'Azur, France
Centre Leon Berard
🇫🇷Lyon, Rhône-Alpes, France
Clinique Victor Hugo Le Mans
🇫🇷Le Mans, Sarthe, France
Universitaetsklinikum Freiburg
🇩🇪Freiburg, Baden-Württemberg, Germany
Universitätsklinikum Frankfurt
🇩🇪Frankfurt, Hessen, Germany
Urologicum Duisburg Fachärztesozietät - Walsum
🇩🇪Duisburg, Nordrhein-Westfalen, Germany
Universitaetsklinikum Tuebingen
🇩🇪Tübingen, Baden-Würt, Germany
NCT
🇩🇪Heidelberg, Baden-Württemberg, Germany
Studienpraxis Urologie
🇩🇪Nürtingen, Baden-Württemberg, Germany
Klinikum Rechts Der Isar Der Technischen Universität München
🇩🇪Munich, Bayern, Germany
Urologische Gemeinschaftspraxis Heinsberg
🇩🇪Heinsberg, Nordrhein-Westfalen, Germany
Universitätsklinikum Münster - Albert Schweitzer Campus
🇩🇪Münster, Nordrhein-Westfalen, Germany
Urologische Gemeinschaftspraxis Wesel
🇩🇪Wesel, Nordrhein-Westfalen, Germany
InVO Institut für Versorgungsforschung in der Onkologie
🇩🇪Koblenz, Rheinland-Pfalz, Germany
Universitätsmedizin Johannes Gutenberg Universität Mainz
🇩🇪Mainz, Rheinland-Pfalz, Germany
Urologie Neandertal - Praxis Mettmann
🇩🇪Mettmann, Germany
Universitaetsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
Klinikum Nürnberg Nord
🇩🇪Nürnberg, Germany
University Hospital of Patras
🇬🇷Patras, Achaḯa, Greece
Agios Savvas Regional Cancer Hospital
🇬🇷Athens, Attikí, Greece
Alexandra Hospital
🇬🇷Athens, Attikí, Greece
Meir Medical Center
🇮🇱Kfar Saba, HaMerkaz, Israel
Rabin Medical Center
🇮🇱Petah Tikva, HaMerkaz, Israel
Sheba Medical Center
🇮🇱Ramat Gan, HaMerkaz, Israel
Yitzhak Shamir Medical Center
🇮🇱Zerifin, HaMerkaz, Israel
Attikon General University Hospital
🇬🇷Chaidari, Attikí, Greece
Magyar Honvedseg Egeszsegugyi Kozpont
🇭🇺Budapest, Hungary
University General Hospital of Heraklion
🇬🇷Heraklion, Irakleío, Greece
Petz Aladar Egyetemi Oktato Korhaz
🇭🇺Gyor, Győr-Moson-Sopron, Hungary
Országos Onkológiai Intézet
🇭🇺Budapest, Pest, Hungary
Rambam Health Care Campus
🇮🇱Haifa, HaTsafon, Israel
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
🇮🇹Meldola, Emilia-Romagna, Italy
Sourasky Medical Center
🇮🇱Tel Aviv, Tell Abīb, Israel
Hadassah Medical Center
🇮🇱Jerusalem, Yerushalayim, Israel
Fondazione Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Lazio, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
🇮🇹Milan, Lombardia, Italy
Istituto Oncologico Veneto IRCCS
🇮🇹Castelfranco Veneto, Veneto, Italy
Istituto Europeo di Oncologia IRCCS
🇮🇹Milano, Italy
Azienda Ospedaliera Santa Maria Terni
🇮🇹Terni, Italy
APSS- Presidio Ospedaliero S. Chiara
🇮🇹Trento, Italy
National Cancer Center Hospital East
🇯🇵Kashiwa, Chiba, Japan
Kimitsu Chuo Hospital
🇯🇵Kisarazu, Chiba, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Chiba, Japan
Hokkaido University Hospital
🇯🇵Sapporo, Hokkaido, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Kanagawa, Japan
Kobe City Medical Center General Hospital
🇯🇵Kobe, Hyogo, Japan
Nagano Municipal Hospital
🇯🇵Tomitake, Nagano, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Ishikawa, Japan
Kagawa University Hospital
🇯🇵Kita, Kagawa, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu, Shizuoka, Japan
Showa University Hospital
🇯🇵Shinagawa, Tokyo, Japan
National Hospital Organization Kumamoto Medical Center
🇯🇵Kumamoto, Japan
Osaka International Cancer Institute
🇯🇵Osaka, Japan
Seoul National University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Actualidad Basada en la Investigación del Cáncer
🇲🇽Guadalajara, Jalisco, Mexico
Health Pharma Professional Research S.A. de C.V:
🇲🇽Ciudad de México, Distrito Federal, Mexico
Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
🇲🇽Culiacan, Sinaloa, Mexico
Scientia Investigacion Clinica S.C.
🇲🇽Chihuahua, Mexico
ETZ Elisabeth
🇳🇱Tilburg, Noord-Brabant, Netherlands
University Medical Center Groningen
🇳🇱Groningen, Netherlands
Centro de Investigacion Clinica de Oaxaca
🇲🇽Oaxaca, Mexico
Clinical Best Solutions
🇵🇱Lublin, Lubelskie, Poland
Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego
🇵🇱Opole, Opolskie, Poland
Szpitale Pomorskie Sp. z o. o.
🇵🇱Gdynia, Pomorskie, Poland
Salve Medica
🇵🇱Lodz, Łódzkie, Poland
Provita Profamilia
🇵🇱Piotrkow Trybunalski, Łódzkie, Poland
Amethyst Radiotherapy Center
🇷🇴Florești, Cluj, Romania
C.M.D.T.A. Neomed
🇷🇴Brasov, Brașov, Romania
Ovidius Clinical Hospital OCH
🇷🇴Ovidiu, Constanța, Romania
Centrul de Oncologie "Sfântul Nectarie"
🇷🇴Craiova, Dolj, Romania
Radiology Therapeutic Center
🇷🇴Otopeni, Ilfov, Romania
Oncopremium Team
🇷🇴Baia Mare, Maramureș, Romania
Centrul medical Focus
🇷🇴București, Romania
Gral Medical Diagnostic Center
🇷🇴București, Romania
Instituto Catalan de Oncologia - Hospital Duran i Reynals
🇪🇸Hospitalet, Barcelona [Barcelona], Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Madrid, Comunidad De, Spain
Hospital Universitario Ramón y Cajal
🇪🇸Madrid, Madrid, Comunidad De, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Madrid, Comunidad De, Spain
National Taiwan University Hospital
🇨🇳Taipei City, Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei City, Taipei, Taiwan
Fundación Instituto Valenciano de Oncología
🇪🇸Valencia, Valenciana, Comunitat, Spain
Hospital Infanta Cristina
🇪🇸Badajoz, Spain
Hospital Universitario Virgen Del Rocio
🇪🇸Sevilla, Spain
China Medical University Hospital
🇨🇳Taichung, Taiwan
Chang Gung Medical Foundation-Linkou Branch
🇨🇳Taoyuan, Taiwan
Medipol Mega Universite Hastanesi
🇹🇷Stanbul, İstanbul, Turkey
Izmir Medical Park Hospital
🇹🇷Izmir, Karsiyaka, İzmir, Turkey
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
Baskent University Dr. Turgut Noyan Research and Training Center
🇹🇷Adana, Turkey
Ankara Bilkent Şehir Hastanesi
🇹🇷Ankara, Turkey
Royal Blackburn Hospital
🇬🇧Blackburn, Blackburn With Darwen, United Kingdom
Colchester General Hospital
🇬🇧Colchester, Essex, United Kingdom
Ankara Universitesi Tip Fakultesi Hastanesi
🇹🇷Ankara, Turkey
Dicle Üniversitesi
🇹🇷Diyarbakir, Turkey
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
🇹🇷Istanbul, Turkey
İnönü Üniversitesi Turgut Özal Tıp Merkezi
🇹🇷Malatya, Turkey
University College London Hospital
🇬🇧London, London, City Of, United Kingdom
The University of Vermont Medical Center Inc.
🇺🇸Burlington, Vermont, United States
University of Massachusetts Chan Medical School
🇺🇸Worcester, Massachusetts, United States
Florida Cancer Specialist- East
🇺🇸West Palm Beach, Florida, United States
Associated Medical Professionals - Urology
🇺🇸Syracuse, New York, United States
The Center for Cancer and Blood Disorders
🇺🇸Fort Worth, Texas, United States
Maimonides Cancer Center
🇺🇸Brooklyn, New York, United States
Fort Wayne Medical Oncology and Hematology
🇺🇸Fort Wayne, Indiana, United States
Orange Coast Memorial Medical Center
🇺🇸Fountain Valley, California, United States
Providence Medical Foundation
🇺🇸Fullerton, California, United States
Chris O'Brien Lifehouse
🇦🇺Camperdown, New South Wales, Australia
University of Tennessee Medical Center
🇺🇸Knoxville, Tennessee, United States
The University of Louisville, James Graham Brown Cancer Center
🇺🇸Louisville, Kentucky, United States
Centro Medico San Roque
🇦🇷San Miguel de Tucumán, Tucumán, Argentina
Ashford Cancer Centre Research
🇦🇺Kurralta Park, South Australia, Australia
Icon Cancer Centre Hobart
🇦🇺Hobart, Tasmania, Australia
Lyell McEwin Hospital
🇦🇺Elizabeth Vale, South Australia, Australia
Universitaetsklinikum Ulm
🇩🇪Ulm, Baden-Württemberg, Germany
Beijing Cancer hospital
🇨🇳Beijing, Beijing, China
Shanghai General Hospital
🇨🇳Shanghai, Shanghai, China
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia