Ropivacaine Use in Femoral Nerve Block; What is the Minimal Effective Analgesic Concentration (MEAC 90)
- Conditions
- Postoperative Pain
- Registration Number
- NCT04834440
- Lead Sponsor
- Healthpoint Hospital
- Brief Summary
The aim of this study is to determine the minimal effective ropivacaine concentration required to provide adequate analgesic femoral nerve block in 90% of patients (MEAC90)
- Detailed Description
* Before induction of GA, all patients will receive sciatic, obturator, lateral femoral cutaneous and femoral nerve blocks.
* The femoral nerve block will be performed using 15ml of ropivacaine which concentration relied on the response of the previous patient.
* Based on biased-coin design up-down sequential method: when a patient has a negative response, the next patient will receive a concentration 0.01% w/v higher. However if he has a positive response, the next patient will be randomized to receive either the same ropivacaine concentration or a concentration 0.01% w/v less.
* Patients with pain free recovery will be considered to have positive response.
* Patients' responses will be analyzed to calculate the MEAC90
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 45
- Patients, who are scheduled for knee ligament reconstruction
-
<18 y,
-
ASA physical class greater >III
- BMI >40 has any contraindication for medications or techniques used in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method effective analgesic femoral nerve block in recovery unit (one hour after surgery) postoperative pain. it will be assessed using numerical rating scale (NRS). NRS, 0 = no pain; 10 = worst pain imaginable; if NRS ≥ 3, pain (ineffective block) is considered, other wise a successful block will be considered.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Healthpoint Hospital
🇦🇪Abu Dhabi, United Arab Emirates