Seasonal assessment of existing immunity for respiratory viruses in healthy volunteers to facilitate targeted vaccine development - a preparatory study

Recruiting

• Conditions: respiratory tract infections; viral infection; 10024970

• Registration Number: NL-OMON56235
• Lead Sponsor: Centre for Human Drug Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 3500

Inclusion Criteria

1. Age 18-75 years and in good health; the upper age limit could be lowered for
different executions of this protocol, but will never exceed 75 years.
2. Good health, based upon the results of medical history.
3. Subject has signed informed consent.

Exclusion Criteria

1. Evidence of immunodeficiency in medical history
2. Prior use of immunosuppressive medication (systemic glucocorticoids six
months prior to inclusion or any other systemic immunosuppressive medication at
any time), immunoglobulins or systemic antiviral therapy)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess existing background immunity for respiratory virus stems in the<br /><br>general population using laboratory assessments containing, but not limited to:<br /><br>• Hemagglutination inhibiton assay (HAI) titre for selected viral stems, for<br /><br>Influenza<br /><br>• Microneutralization assay (MN) titre for selected viral stems<br /><br>• (Neutralizing) IgG & IgA titre for selected viral stems</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>