Comparison of Subarachnoid Block in Mixed Versus Sequential Administration of Levobupivacaine and Dexmedetomidine in Lower Limb Surgeries: A Randomized Clinical Study

The aim behind performing this study is to see differences in sensory and motor block characteristics along with determining effects on haemodynamics while intrathecal administration of premix hyperbaric Levobupivacaine and Dexmedetomidine in single syringe or in two separate syringes.

58 patients for lower limb surgeries will be randomly decided into two groups , In each group there will be 29 patients who are posted for elective lower limb surgeries.

In one group Group M -  - Inj Levobupivacaine 0.5% (12.5mg) 2.5ml + Inj Dexmedetomidine (10mcg) 0.5 ml (Diluted in Normal saline).  (premix). Total drug prepared will be 3ml in a single 5cc syringe. In second group Group S - Inj Levobupivacaine 0.5% (12.5mg) 2.5 ml (in 5cc syringe) followed by Inj Dexmedetomidine (10mcg) 0.5ml (Diluted in Normal saline in 2cc syringe). (Two syringe technique – drugs will be loaded in two separate syringes).

Comparing Sensory and Motor block characteristics as primary outcome

As a secondary outcome  , hemodynamic parameters ,duration of effective analgesia , requirement of rescue analgesia in 24 hours ,any complications will be assessed .

The proposed advantage of the study will be that Dexmedetomidine and Levobupivacaine given sequentially results in faster onset of sensory and motor block, prolongs the duration and reduces the postoperative analgesic requirement as compared to premixed drugs .