NL-OMON39934已完成不适用
The effect of Roux-en-Y gastric bypass surgery in morbidly obese patients on Pharmacokinetics of (Acetyl)salicylic acid and Omeprazole. - ERY-PAO
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Male or female aged between 18 and 65 years at the time of informed consent.
- •- Written informed consent
- •- Scheduled to undergo RYGB surgery and approved to undergo this procedure according to the inclusion criteria of NOK West (Dutch Obesity Clinic West)
- •- Ability to swallow whole medication tablets
排除标准
- •- Ulceration or leakage of the anastomosis post-surgery, to be determined 6 weeks after the RYGB surgery by the surgeon. This is an exclusion criterium for the second testday, to be determined during the study)
- •- *Redo* patients: patients previously treated for morbid obesity with a gastric sleeve or gastric banding.
- •- Contra-indication to use ASA or omeprazole, e.g. known or suspected allergy
- •- Present use or use of drugs within 4 times the half-life of that drug before the start of the study that might interfere with the metabolism of the investigational drugs (inducers/inhibitors of CYP2C19)
- •- Concurrent disease or increased risk of bleeding which may compromise safety of the administration of the study medication (e.g. Von Willebrands disease) according to the judgement of the investigator.
- •- Gastro-intestinal disorders which may impair drug absorption (e.g. Crohn's disease or previous stomach or bowel surgery) according to the judgement of the investigator.
- •- Treatment with any unlicensed drug during the previous month.
研究者
相似试验
招募中
4 期
The effect of Roux-en-Y Gastric Bypass surgery in morbidly obese patients on pharmacokinetic of lansoprazoleMorbidly ObesityRoux-en-y Gastric bypass, Lansoprazole, PharmacokineticsTCTR20220118001Ratchadapisek Sompoch Endowment Fund Chulalongkorn university16
进行中（未招募）
不适用
The effect of a gastric bypass surgery on the absorption of acetylsalicylic acid and omeprazole after ingestion.Roux-en-Y gastric bypass (RYGB) surgery is a successful treatment for morbid obesity. In this procedure, a small gastric pouch is created. The duodenum is bypassed by connecting the jejunum to this stomach pouch. The duodenum is then connected to a lower part of the jejunum to ensure passage of bile salts and pancreatic enzymes.EUCTR2012-005387-10-NLDepartment of hospital Pharmacy, Medical Centre Haaglanden
已完成
不适用
The effect of Roux-en-Y gastric bypass on the rate and extent of absorption of metoprolol from a controlled release tablet in female bariatric patient volunteers: a single oral dose study before and after surgeryRoux-en-Y gastric bypassweight loss surgery10017998NL-OMON38920Medisch Centrum Leeuwarden10
尚未招募
不适用
Effect of RYGB on the absorption of metoprolol controlled release.Roux- en Y gastric bypassmetoprololcontrolled release tabletabsorptiongastric bypassmetoproltablet met gereguleerde afgifteabsorptieNL-OMON21648Medisch Centrum LeeuwardenLeeuwarden10
尚未招募
不适用
A study on the effect of gastric bypass on the absortpion of metoprolol immediate release tablet.Roux- en-Y gastric bypass<br />Metoprolol<br />immediate release tabletabsorptiongastric bypassmetoprololdirecte afgifte tabletabsorptieNL-OMON29306Medisch Centrum Leeuwarden10