The Physical Activity Post Myocardial Infarction SWEDEHEART Prospective Cohort Study

Recruiting

• Conditions: Myocardial Infarction
• Interventions: Other: Accelerometer measurement

• Registration Number: NCT05339477
• Lead Sponsor: Sahlgrenska University Hospital

Brief Summary

The association between objectively measured physical activity intensities (light, moderate and vigorous), sedentary time and clinical outcomes has not been clarified in patients after a myocardial infarction.

The overall objective of the study is to explore associations between accelerometer measured physical activity and clinical outcomes after a myocardial infarction. Moreover, the association between changes in physical activity and outcomes will be assessed.

Detailed Description

It is estimated to include 4000 patients with myocardial infarction during 2 years. Patients will wear the accelerometer for 7 days at follow-up visits (2 months and 1 year) after discharge. The investigators will examine the dose-response relations of several exposure variables from the accelerometer measurements with the outcomes.

Study Timeline

• Study First Submitted: 2022-04-10
• Study First Submitted QC: 2022-04-14
• Study First Posted: 2022-04-21
• Study Start: 2022-04-26
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-09
• Last Update Posted: 2025-02-11
• Primary Completion: 2026-04-26
• Study Completion: 2029-04-26

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

• Signed informed consent
• Diagnosis of a type 1 myocardial infarction registered in SWEDEHEART
• Age 18-79 years at discharge from hospital
• Attending the first visit in the cardiac rehabilitation (CR) registry SEPHIA (2 months after discharge)

Exclusion Criteria

• Inability to understand Swedish
• Non-ambulatory
• Any mental condition that may interfere with the possibility for the patient to comply with the study protocol

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cohort group	Accelerometer measurement	Diagnosis of a type 1 myocardial infarction registered in SWEDEHEART Age 18-79 years at discharge from hospital

Primary Outcome Measures

Name	Time	Method
Major adverse cardiovascular event (MACE)	1 year after the index cardiac event	The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure

Secondary Outcome Measures

Name	Time	Method
Non-fatal myocardial infarction	3 years after the index cardiac event	Incidence of non-fatal myocardial infarction
Cardiovascular mortality	3 years after the index cardiac event	Incidence of cardiovascular mortality
Major adverse cardiovascular event (MACE)	3 years after the index cardiac event	The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure
All-cause death	3 year after the index cardiac event	Incidence of all-cause death
Non-fatal ischemic stroke	3 years after the index cardiac event	Incidence of non-fatal ischemic stroke
Heart failure	3 years after the index cardiac event	Incidence of hospitalization for new or worsening heart failure
Coronary revascularization	3 years after the index cardiac event	Incidence of coronary revascularization

Trial Locations

Locations (35)

Alingsås lasarett; 🇸🇪 Alingsås, Sweden

Bollnäs sjukhus; 🇸🇪 Bollnäs, Sweden

NU-sjukvården Dalslands sjukhus; 🇸🇪 Bäckefors, Sweden

Höglandssjukhuset Eksjö; 🇸🇪 Eksjö, Sweden

Lasarettet Enköping; 🇸🇪 Enköping, Sweden

Sahlgrenska University Hospital Sahlgrenska; 🇸🇪 Gothenburg, Sweden

Gävle sjukhus; 🇸🇪 Gävle, Sweden

Helsingborgs lasarett; 🇸🇪 Helsingborg, Sweden

Jönköping Ryhov Hospital; 🇸🇪 Jönköping, Sweden

Kalix sjukhus; 🇸🇪 Kalix, Sweden

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