CTRI/2018/12/016531招募中2 期
A randomized controlled pilot trial to compare the efficacy of Rituximab infusion versus intravenous Dexamethasone Pulse therapy in Pemphigus vulgaris and its correlation with phenotypic and functional determinants of B and T cells
DR SUJAY KHANDPUR0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Subject with active PV fulfilling any of the two criteria mentioned below:
- •-Clinical signs typical of pemphigus vulgaris and
- •-Histological features of suprabasal acantholysis on hematoxylin and eosin staining
- •-Positive ELISA test for anti dsg1 and dsg3 antibodies
- •2. Patients giving consent for obtaining blood and skin biopsy samples for various investigations
- •3. Patients who can obtain i.v. Rituximab (1g 2 doses)
排除标准
- •1.Pure mucosal pemphigus vulgaris
- •2.Age <18 or > 70 years
- •3.Has received prior biological therapy in past 2 months
- •4.Pregnant or lactating women.
- •5.Patients with severe renal or hepatic disease
- •6.Evidence of paraneoplastic pemphigus
- •7.Autoimmune blistering disease other than PV
- •8.Active, unhealed peptic ulcer within 3 months prior to randomization
- •9.Inherited or acquired immune deficiency
- •10.Malignancy, lymphoproliferative diseases or previous total lymphoid irradiation
- •11.Chronic or frequent drug resistant, bacterial infections or presence of severe active infection
- •12.Bone marrow insufficiency
- •13.Frequent and / or serious viral infections.
- •14.Systemic or invasive fungal disease within 2 years prior to randomization
研究者
相似试验
已完成
4 期
Can Heart Rate Variability analysis reduce analgesic requirements after laparoscopic cholecystectomy?cholecystectomyAnaesthesiology - Pain managementACTRN12612000953831Peninsula Health (Frankston Hospital)100
已完成
不适用
A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a primary Dupuytren*s contracture with standard fasciectomy surgery on convalescence, contracture correction and recurrence rate.Dupuytren's contracturehand diseases1001076110040795NL-OMON31898Erasmus MC, Universitair Medisch Centrum Rotterdam80
已完成
不适用
A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.hand diseasesSecondary Dupuytren's contracture1001076110040795NL-OMON34920Erasmus MC, Universitair Medisch Centrum Rotterdam80
进行中（未招募）
1 期
Efficacy of topical coal tar in children with atopic dermatitisAtopic dermatitisMedDRA version: 19.1Level: LLTClassification code 10003639Term: Atopic dermatitisSystem Organ Class: 100000004858EUCTR2016-004542-28-NLRadboud University Medical Center80
已完成
4 期
A randomized controlled pilot study comparing the efficacy of topical coal tar to topical corticosteroids in children aged 1 to < 16 years with moderate-severe atopic dermatitis.Atopic dermatitisNL-OMON42910Radboud Universitair Medisch Centrum80