Effect of Preoperative Oral Carbohydrates on Postoperative Nausea and Vomiting and Quality of Recovery in DM Patients Undergoing Total Knee Arthroplasty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- Incidence of postoperative nausea and vomiting
研究概览
简要总结
The primary purpose of this study is to investigate the effects of carbohydrate-rich drink on postoperative nausea and vomiting in diabetic patients undergoing total knee arthroplasty. The secondary purpose is to investigate the effects of carbohydrate-rich drink on quality of recovery and inflammation in diabetic patients after total knee arthroplasty.
详细描述
Carbohydrate-rich drink has been proved to neither delay gastric emptying nor affect gastric acidity and is therefore considered safe to use in elective surgical patients without risk factors for pulmonary aspiration. It reduced postoperative nausea and vomiting and improved sense of well-being after surgery. Moreover, carbohydrate-rich drink was not found to be affected by delayed gastric emptying in patients with uncomplicated type 2 diabetes. Therefore, carbohydrate drink may be safely administered 3 h before anesthesia without risk of hyperglycemia or aspiration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 DM patients undergoing elective total knee arthroplasty
排除标准
- •Contraindication to regional anesthesia
- •Patients whose operation is scheduled to start after 9:00 am
- •Dementia or cognitive dysfunction
- •HbA1c > 8%
- •Gastroesophageal reflux disease
研究组 & 干预措施
Carbohydrate group
Carbohydrate-rich drink 400 mL 3 h before surgery
干预措施: Carbohydrate-rich drink (Dietary Supplement)
Control group
10% dextrose solution mixed with insulin 16 unit 100 mL/h
干预措施: 10% dextrose solution mixed with insulin 16 unit 100 mL/h (Dietary Supplement)
结局指标
主要结局
Incidence of postoperative nausea and vomiting
时间窗: 24 hours
次要结局
- Score of quality of recovery(24 hours)
- Degree of inflammation(24 hours)
研究者
So Yeon Kim
Assistant professor
Severance Hospital