Retinal Oxygen Reactivity in Patients Infected With Human Immunodeficiency Virus (HIV).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Reactivity in retinal blood flow during 100% O2 breathing expressed as percent change
研究概览
简要总结
Ocular lesions, including cotton wool spots and retinal hemorrhage, are a common feature of HIV infection and acquired immunodeficiency syndrome (AIDS). The aetiology of these apparently vasoocclusive phenomena in HIV related retinopathy is not well understood. Several hypotheses including infectious damage of the retinal vasculature and altered retinal hemodynamics have been postulated. The latter would be compatible with the theory that the retina of HIV patients is hypoxic. However, direct measurement of oxygen tension in the retina is not possible and indirect methods have to be employed. The study objective was to investigate the reactivity in retinal blood flow to 100% oxygen breathing in patients with HIV.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Group 1 (Patients with HIV)
- •Aged between 19 and 70 years, male and female
- •HIV positive patients without HIV-related retinopathy with a CD4+ cell count 500 cells/mm3 stage A2, A3, B2, B3, C2 and C
- •Best corrected visual acuity >= 0.8
- •Ametropy < 6 dpt
- •Group 2 (Healthy control subjects)
- •Aged between 19 and 70 years
- •Age and sex matched to the subjects in the HIV group (group matched)
- •Matched with regard to the smoking habits in the HIV group
- •Best corrected visual acuity >= 0.8
- •Ametropy < 6 dpt
排除标准
- •Evidence of any other eye disease
- •Diabetes mellitus
- •Systemic hypertension (defined as SBP > 150 mmHg or DBP > 90 mmHg)
- •Abuse of illegal drugs
结局指标
主要结局
Reactivity in retinal blood flow during 100% O2 breathing expressed as percent change
次要结局
未报告次要终点