CARACTERIZACIÓN CLÍNICA Y ENDOSCÓPICA DE PACIENTES CON MÚLTIPLES ADENOMAS COLORRECTALES: ESPAPOLIP
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- colorectal cancer incidence
研究概览
简要总结
The aim is to clinically, endoscopically, and molecularly characterize patients with multiple colorectal adenomas, establish the indication for genetic testing to rule out hereditary syndromes and identify the genes to be included, and improve endoscopic screening recommendations for these patients and their relatives.
详细描述
HYPOTHESIS
Better characterization of patients with MAC (multiple adenomatous colorectal polyps) could help identify predictive factors of germline pathogenic variants.
Identifying predictive factors of germline pathogenic variants would help optimize and standardize selection criteria for MAC patients to undergo genetic panel testing.
The identification of extra-colonic manifestations in these patients would help implement relevant screening strategies.
Studying the incidence of advanced neoplasia in surveillance colonoscopies in MAC patients would help optimize the intervals for endoscopic surveillance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •10 or more adenomas
- •>18 years
排除标准
- •Inhereted condictions
- •Inflammatory bowel disease
结局指标
主要结局
colorectal cancer incidence
时间窗: 5 years
incidence of invasive CRC
次要结局
未报告次要终点