Mixed Meal Challenge and Insulin Resistance

Not Applicable

• Conditions: Insulin Resistance; Metabolic and Endocrine - Metabolic disorders; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12624000306516
• Lead Sponsor: Deakin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-03-22
• Last Update Posted: 1 April 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 255

Inclusion Criteria

1. Fasting blood glucose <= 6.0 mM
2. 35-75 years old

PLUS at least one of the below risk factors for insulin resistance:
i). Overweight/obese (body mass index >=25 kg/m2).
ii). Elevated blood pressure (defined as seated blood pressure >130/85 mmHg, or on medication to control blood pressure).
iii). Abnormal blood lipids (fasting triglycerides >1.7 mM, total cholesterol >5.5 mM or high density lipoproteins <1.0 mM for males or <1.3 mM for females, or on medication to treat their lipids).
iv). Have a parent with type 2 diabetes or a parent with premature onset cardiovascular disease (males <=55 years, females <=65 years).
v). Prior history of gestational diabetes (for females).

Exclusion Criteria

1. Have type 2 diabetes or elevated fasting blood glucose (> 6.0 mM).
2. <35 or >75 years old.
3. On medication known to alter insulin sensitivity or blood glucose levels
(e.g. metformin, glucocorticoids).
4. Have cardiovascular disease (e.g. previous heart attack, stroke, pacemaker etc).
5. Pregnant or lactating.
6. Lactose/dairy intolerance or people abstaining from dairy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified