The Predictors for Continuous Renal Replacement Therapy in Liver Transplant Patient
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Yonsei University
- Enrollment
- 148
- Locations
- 1
- Primary Endpoint
- the amount of ascites
Study Overview
Brief Summary
Background. Acute renal failure after liver transplantation (LT) requiring continuous renal replacement therapy (CRRT) adversely affects patient survival. However, there are few reports to assess the predictors for postoperative CRRT in liver transplant patients. The investigators undertook this study to identify perioperative factors that would predict patients at risk of CRRT.
Patients and Methods. The investigators retrospectively reviewed the data of 148 liver transplant patients from January 2007 to November 2010 at Severance Hospital, Yonsei University HealthSystem, in Seoul, Korea. The number of patients treated with CRRT was 44 (18 patients from living and 26 from deceased donors) and those without CRRT was 104. Univariate and stepwise logistic multivariate analyses were performed.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 19 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age 19-65 year
- •Liver transplant patients from January 2008 to December 2011
Exclusion Criteria
- •Patients treated with CRRT before transplantation
Outcomes
Primary Outcomes
the amount of ascites
Time Frame: intraoperative
Intraoperative urine output
Time Frame: intraoperative
the duration of anesthesia and operation
Time Frame: intraoperative
intraoperative hemodynamic instability
Time Frame: intraoperative
intraoperative bleeding
Time Frame: intraoperative
status before operation
Time Frame: 1 day before operation
laboratory data(ex : total bilirubin, albumin, coagulation factors, blood gas analysis(arterial CO2 pressure. Blood urea nitrate/Creatinine, Hemoglobin/Hematocrit.)
the types of donation(living or deceased donor)
Time Frame: intraoperative
survival rate
Time Frame: on the postoperative 28th days, 365 days
postoperative bleeding amount
Time Frame: on the postoperative 28th days, 365 days.
postoperative CRRT(continuous renal replacement therapy),
Time Frame: on the postoperative 28th days, 365days
mortality
Time Frame: on the postoperative 28th days, 365 days.
Secondary Outcomes
No secondary outcomes reported