Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant

Not Applicable

Withdrawn

• Conditions: Acute Kidney Injury; End Stage Kidney Disease; Liver Disease; Chronic Kidney Disease
• Interventions: Procedure: Renal replacement therapy

• Registration Number: NCT01619449
• Lead Sponsor: University of Chicago

Brief Summary

To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters. The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is associated with increased solute removal and improved acid-base statues when compared to controls who do not receive CRRT

Detailed Description

as above

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-04
• Study First Submitted: 2012-06-12
• Study First Submitted QC: 2012-06-13
• Study First Posted: 2012-06-14
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-27

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Age 18 or older and able to sign consent (or surrogate)
• Receiving liver or combined liver-kidney transplant
• eGFR < or equal to 40 ml/min immediately prior to transplant or currently on any form of renal replacement therapy for acute kidney injury or end-stage renal disease
• Pre-operative potassium of < or equal to 5.5 mEq/L

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Exclusion Criteria

• Pre-operative hemoglobin < or equal to 7 g/dL
• Pre-operative weight > or equal to 125 kig

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Renal replacement therapy	Renal replacement therapy	Liver transplant recipients who receive continuous renal replacement therapy intra-operatively.
No CRRT	Renal replacement therapy	This arm consists of standard of care without CRRT in the OR for OLT

Primary Outcome Measures

Name	Time	Method
Solute Clearance	Intra-operative time	To compare the clearance of solutes (ie. potassium, lactate, creatinine and blood urea nitrogen) by CRRT in renally impaired OLT recipients to OLT recipients who do not receive CRRT

Secondary Outcome Measures

Name	Time	Method
Renal function and patient outcomes	1 year post-operatively	To compare long-term maintenance of renal function (12 months) and other health outcomes in OLT recipients who received CRRT versus OLT recipients who did not receive OLT

Trial Locations

Locations (1)

University of Chicago Medicine; 🇺🇸 Chicago, Illinois, United States