NCT01619449撤回不适用
Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant: A Randomized Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Solute Clearance
研究概览
简要总结
To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters. The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is associated with increased solute removal and improved acid-base statues when compared to controls who do not receive CRRT
详细描述
as above
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 or older and able to sign consent (or surrogate)
- •Receiving liver or combined liver-kidney transplant
- •eGFR < or equal to 40 ml/min immediately prior to transplant or currently on any form of renal replacement therapy for acute kidney injury or end-stage renal disease
- •Pre-operative potassium of < or equal to 5.5 mEq/L
排除标准
- •Pre-operative hemoglobin < or equal to 7 g/dL
- •Pre-operative weight > or equal to 125 kig
结局指标
主要结局
Solute Clearance
时间窗: Intra-operative time
To compare the clearance of solutes (ie. potassium, lactate, creatinine and blood urea nitrogen) by CRRT in renally impaired OLT recipients to OLT recipients who do not receive CRRT
次要结局
- Renal function and patient outcomes(1 year post-operatively)
研究者
研究点 (2)
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