Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction
- Conditions
- Myocardial Infarction
- Interventions
- Other: exosome
- Registration Number
- NCT04127591
- Brief Summary
The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.
- Detailed Description
Collect exosomes in peripheral blood of patients with myocardial infarction, compare the expression of miRNA with healthy volunteers, find out the miRNAs with significant differences, and explore its relationship with the development of myocardial infarction.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Age > 18 years ST elevation by ECG diagnostic of STEMI Evidency of coronary occlusion in coronariography Signed informed consent
Exclusion Criteria
- Patients who will undergo immediate PCI Pregnant and lactating women Patients with mental disorders Patients are using other experimental drugs; Refusal to provide informed.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description myocardial infarction group exosome Patients admitted with the diagnosis of myocardial infarction. Blank control group exosome Patients admitted without the diagnosis of myocardial infarction.
- Primary Outcome Measures
Name Time Method Determination of differential expression of miRNA by second-generation sequencing technology Day 7
- Secondary Outcome Measures
Name Time Method Diagnostic value of the differential microRNAs evaluate by qPCR in patients of myocardial infarction Day 7
Trial Locations
- Locations (1)
Ethics Committee of Xinhua Hospital
🇨🇳Shanghai, Shanghai, China