Influence of Preconceptional Obesity on the Myometrial Cells Differentiation Toward a Contractyl Phenotype
- Conditions
- Pregnancy Complication
- Registration Number
- NCT01762683
- Lead Sponsor
- Centre Hospitalier Universitaire Dijon
- Brief Summary
The purpose of this study is to improve the understanding of cellular mecanism involved in delivery disorders in obese women, first by characterizing the hyperplasia phenomenon of myometrail cells induced by inflammatory stimulation (Il-1B), then by studying the role of blood mononuclear cells, of leptine and of obese women sera to interfere with the transition of myometrial cells toward hyperplasia phenotype.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 38
- Informed consent signed
- Patient affiliated with a social security scheme
- In front of for obstetrical reasons to give birth by caesarean section (scheduled caesarean section)
- Or a woman who is not obese in labour and needs to undergo a cesarean section
- No obvious infectious context
- Age > 18 years old
- Obvious inflammatory or autoimmune diseases
- Suspected or confirmed infectious context, including virale infection VIH, VHC, VHB
- Coagulation disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Measuring the expression level of markers (Gama actine, Desmine, Connexine-43, and Ocytocine receptor) by Westernblotting up to 2 months Demonstrate in vitro the capacity of a Il-1B stimulus to induce the differentiation of the myometrial cells toward a hyperplasia phenotype, and that the answer depends on whether this is cells from normal weight women or obese women before conception.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Maternité du CHU de Dijon
🇫🇷Dijon, Bourgogne, France
Clinique Sainte Marthe
🇫🇷Dijon, France
Maternité du CHU de Dijon🇫🇷Dijon, Bourgogne, France