Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidation

Not Applicable

Completed

• Conditions: Obesity; Type 2 Diabetes Mellitus
• Interventions: Dietary Supplement: Effect of the green tea extract TEAVIGO, high in EGCG, on postprandial fat oxidation

• Registration Number: NCT00867555
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

The body of evidence regarding the health benefits of green tea has grown considerably during the last decade and includes antioxidant properties, anti- cancer, anti-obesity and anti-diabetes effects. There has been evidence that green tea extract favorably affect body weight and body fat and has positive effects on blood glucose control

Aim of this study is to investigate the short term effect (3-day)of TEAVIGO (high in the catechin EGCG) on postprandial fat oxidation during different phases of the postprandial period in overweight subjects. Secondly, in a subset of volunteers changes in lipolysis and glucose metabolism will be studied in skeletal muscle and adipose tissue.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2009-03-23
• Study First Submitted QC: 2009-03-23
• Study First Posted: 2009-03-24
• Primary Completion: 2009-05
• Study Completion: 2009-05
• Status Verified: 2009-09
• Last Update Submitted: 2009-09-17
• Last Update Posted: 2009-09-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Age between 20 and 50 y
• BMI 25.0-29.9 kg/m2
• Normal fasting glucose <6.1 mmol/L
• Blood pressure (systolic blood pressure 100-150 mmHg, diastolic blood pressure 60-90 mmHg)
• Weight stable in last 3 months (±2 kg)

Exclusion Criteria

• pregnant, lactating or (post)menopausal women
• regular smokers
• people with intensive fitness training eg athletes
• habitual consumption of green or black tea (more than 1 or 2 cups a day, respectively)
• not more than 300 mg/day caffeine consumption

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
EGCG	Effect of the green tea extract TEAVIGO, high in EGCG, on postprandial fat oxidation	Double blind randomized, placebo-controlled cross-over design with two arms: * the green tea extract TEAVIGO, high in EGCG and * placebo
placebo	Effect of the green tea extract TEAVIGO, high in EGCG, on postprandial fat oxidation	-

Primary Outcome Measures

Name	Time	Method
postprandial fat oxidation	8 months

Trial Locations

Locations (1)

Dept Human Biology, Maastricht University; 🇳🇱 Maastricht, Netherlands