During surgery, blockade of celiac plexus for pain relief in patients having inoperable pancreatic or gastric or gall bladder cancer.

Phase 4

Recruiting

Conditions: Malignant neoplasm of ill-definedsites within the digestive system,

Registration Number: CTRI/2018/05/013667

Lead Sponsor: All India Institute of Medical Sciences AIIMS

Brief Summary: This trial will be conducted in patients having pancreatic, stomach and gall bladder cancer who will be planned for curative resection but found inoperable during surgery. Since these patients have poor prognosis and also complains of severe abdominal pain affecting quality of life. So, intraoperative celiac plexus neurolysis will be done and its analgesic efficacy will be compared with pharmacological therapy for management of postoperative pain on day 1, 2 and 3 in these patients.This study will also compare cumulative morphine consumption and assessment of severity of pain and quality of life in both groups at 1, 3 and 6 months after neurolytic procedure

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 40

Inclusion Criteria

40 patients of American Society of Anesthesiologist (ASA) physical status I, II and III of age group >18 years of either sex admitted at Dr BRA IRCH AIIMS and scheduled to undergo curative surgeries for pancreatic, stomach and gall bladder carcinoma but found unresectable at the time of laparotomy under general anaesthesia.

Exclusion Criteria

Patient refusal 2.
Respiratory insufficiency 3.
Haemodynamic instability 4.
Abnormal thyroid function 5.
Renal or hepatic insufficiency, 6.
History of any chronic pain 7.
Unstable personality and abuse liability.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the analgesic efficacy of intraoperative celiac plexus neurolysis with pharmacological therapy for management of postoperative pain on day 1, 2 and 3 in patients with unresectable pancreatic, stomach and gall bladder cancer.	Postoperative day 1,2 and 3

Secondary Outcome Measures

Name	Time	Method
Cumulative morphine consumption	Severity of pain and quality of life

Trial Locations

Locations (1): All India Institute of Medical Sciences AIIMS
🇮🇳
South, DELHI, India
All India Institute of Medical Sciences AIIMS
🇮🇳South, DELHI, India
Dr Vinod Kumar
Principal investigator
01125795106
vkchanpadia@gmail.com