Evaluating Fractional Flow Reserve computed from Cardiac CT images

Completed

• Conditions: Cardiovascular: coronary artery disease; Circulatory System

• Registration Number: ISRCTN11449939
• Lead Sponsor: Royal Liverpool and Broadgreen University Hospitals NHS Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-12-13
• Last Update Posted: 8 January 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Correlation of CT-FFR with stress CMR/ICA:
1. Aged 18 years or more
2. Undergoing CTCA for assessment of stable chest pain due to possible coronary artery disease who then go on to either stress CMR or ICA for further assessment of coronary artery disease reported on CTCA

CT-FFR in coronary artery stented patients
1. Aged 18 or more
3. Coronary artery stent(s) undergoing CTCA for assessment of stable chest pain due to possible coronary artery disease who then go onto ICA for further assessment of coronary artery disease reported on CTCA

Exclusion Criteria

Correlation of CT-FFR with stress CMR/ICA:
1. Aged <18 years
2. Pregnancy
3. CKD with eGFR <30mL/min/1.73m2
4. Claustrophobia precluding CMR
5. Allergy to either iodinated (CT/ICA) or gadolinium based (CMR) contrast
6. Severe airways disease or high-degree heart block (Mobitz II/CHB) precluding regadenoson/adenosine CMR stress
7. Inability to peripherally cannulate patient for contrast administration
8. Learning difficulties/cognitive impairment precluding informed consent
9. Patient declines participation
10. Patients with stents will be excluded from this component of the study as they will be studied specifically in the second section of the study (below). We will know about the presence of a stent before the CTCA is performed (if referrer informs us or if not, we ask all patients if they have had stent(s)).

CT-FFR in coronary artery stented patients
1. Aged <18 years
2. Pregnancy
3. CKD with eGFR <30mL/min/1.73m2
4. Allergy to iodinated (CT/ICA) contrast
5. Inability to peripherally cannulate patient for contrast administration
6. Learning difficulties/cognitive impairment precluding informed consent
7. Patient declines participation

Study & Design

• Study Type: Observational
• Study Design: Not specified